Evidence map›Paper›PMID 38053980›Full record

ArticleAdvanced functional materials2020

Engineered Heterochronic Parabiosis in 3D Microphysiological System for Identification of Muscle Rejuvenating Factors.

Yunki Lee, Jeongmoon J Choi, Song Ih Ahn, Nan Hee Lee, Woojin M Han, Mahir Mohiuddin, Eun Jung Shin, Levi Wood, Ki Dong Park, YongTae Kim and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced functional materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Direct-Ink-Writing 3D-Printed Bioelectronics.Materials today (Kidlington, England) · 2023
    Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Yunki LeeGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Jeongmoon J ChoiSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Song Ih AhnGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Nan Hee LeeSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Woojin M HanGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Mahir MohiuddinSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Eun Jung ShinSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Levi WoodGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Ki Dong ParkDepartment of Molecular Science and Technology, Ajou University, Suwon 16499, Republic of Korea.
YongTae KimGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Young C JangSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Georgia Institute of Technology · USAjou University · KR

Funding

Probing the functional heterogeneity of high-density lipoprotein using physiological biomimicryDP2HL142050 · NHLBI · GEORGIA INSTITUTE OF TECHNOLOGY · PI KIM, YONGTAE · 2017 to 2017
$2.4M
Engineered Heterochronic Parabiosis on 3D Microphysiological SystemsR01AG072309 · NIA · GEORGIA INSTITUTE OF TECHNOLOGY · PI JANG, YOUNG CHARLES · 2021 to 2025
$1.9M
Advanced Delivery of Microglial Kv1.3 Channel Blocker for Attenuation of Neuroinflammation of Alzheimer's DiseaseR21AG056781 · NIA · GEORGIA INSTITUTE OF TECHNOLOGY · PI KIM, YONGTAE, RANGARAJU, SRIKANT · 2018 to 2019
$424k
Replicating heterochronic parabiosis on a 3D microfluidic chip to study systematic regulation of muscle stem cellR56AG063928 · NIA · GEORGIA INSTITUTE OF TECHNOLOGY · PI JANG, YOUNG CHARLES · 2019 to 2019
$384k
Implantable biofunctional hydrogel for muscle stem cell transplantationR21AR072287 · NIAMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI JANG, YOUNG CHARLES · 2017 to 2018
$377k
Replicating heterochronic parabiosis on a chip for testing anti-geronic factorsR03AG062976 · NIA · GEORGIA INSTITUTE OF TECHNOLOGY · PI JANG, YOUNG CHARLES · 2019 to 2020
$316k
NHLBI NIH HHS DP2 HL142050NIAMS NIH HHS R21 AR072287NIA NIH HHS R01 AG072309NIA NIH HHS R03 AG062976NIA NIH HHS R21 AG056781NIA NIH HHS R56 AG063928
6 · The paper itself

Abstract

Exposure of aged mice to a young systemic milieu revealed remarkable rejuvenation effects on aged tissues, including skeletal muscle. Although some candidate factors have been identified, the exact identity and the underlying mechanisms of putative rejuvenating factors remain elusive, mainly due to the complexity of

Indexed as

agingmicrofluidicsmuscle stem cellmuscle stem cell nicheorgan-on-a-chipparabiosis

Identifiers

PMID38053980
PMCPMC10697693
OpenAlexW3080351408

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.