ArticleJournal of human kinetics2023
The Role of AGT, AMPD1, HIF1α, IL-6 Gene Polymorphisms in the Athletes' Power Status: A Meta-Analysis.
Article in Journal of human kinetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.
- Candidate gene polymorphisms and power athlete status: a meta-analytical approach.Journal of physiology and biochemistry · 2025Pooled it
- Examining the relationship between genetic polymorphisms (BDKRB2, GNB3, HIF1A, MCT1, NOS3) and endurance athlete status.European journal of applied physiology · 2024Pooled it
- Review
- Importance of selected genetic determinants on endurance performance and physical strength: a narrative review.Frontiers in physiology · 2025Review
- Impact of theJournal of human kinetics · 2024Article
- Genetic insights into endurance athlete status: A meta-analysis ofJournal of biological methods · 2024Article
- Molecular signatures of sprint, strength, and power performance: Integrating genetic, epigenetic, transcriptomic, and telomeric evidence.Science progressReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This meta-analysis was designed to investigate the relationship between genetic polymorphisms (AGT rs699, AMPD1 rs17602729, HIF1α rs11549465, IL-6 rs1800795) and power athletes' status. Only case-control studies were included in the meta-analysis. A systematic search of the PubMed and Web of Science databases was performed to identify relevant studies and 23 studies met the inclusion criteria for the meta-analysis. The data from the included studies were pooled and analyzed using a random effects or fix effects model. The effect size was calculated as the odds ratio or a risk ratio with 95% confidence intervals. The results showed that certain genetic polymorphisms, AGT rs699 Thr allele, HIF1A rs11549465 Ser allele and AMPD1 rs17602729 C allele, were significantly more prevalent in power athletes (p < 0.05). When examining the genotype frequency distribution of AGT rs699 and AMPD1 rs17602729, significant differences were found in both the dominant and recessive models (p < 0.05). The results indicate that these gene polymorphisms play a role in power athlete status, however, new and more comprehensive studies are needed to confirm these results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.