Autophagy of umbilical cord mesenchymal stem cells induced by rapamycin conduces to pro-angiogenic function of the conditioned medium.

Wenya Wang, Xiao Li, Chaochu Cui, Guotian Yin, Wenjie Ren, Xianwei Wang

Open access · goldAbstract read

In one paragraph

Article in Biochemistry and biophysics reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.3field-weighted citation impact, top 32% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

Application of autophagy in mesenchymal stem cells.World journal of stem cells · 2024
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Wenya WangHenan Key Laboratory of Medical Tissue Regeneration, Xinxiang Medical University, Xinxiang, China.

Xiao LiHenan Key Laboratory of Medical Tissue Regeneration, Xinxiang Medical University, Xinxiang, China.

Chaochu CuiHenan Key Laboratory of Medical Tissue Regeneration, Xinxiang Medical University, Xinxiang, China.

Guotian YinHenan Key Laboratory of Medical Tissue Regeneration, Xinxiang Medical University, Xinxiang, China.

Wenjie RenClinical Medical Center of Tissue Engineering and Regeneration, Xinxiang Medical University, Xinxiang, China.

Xianwei WangHenan Key Laboratory of Medical Tissue Regeneration, Xinxiang Medical University, Xinxiang, China.

Xinxiang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Angiogenesis is critical for wound healing and tissue repair. Umbilical cord mesenchymal stem cells (UCMSCs)-conditioned medium has certain actions to promote angiogenesis, and is expected for wound healing and tissue repair. However, recent studies showed that the pro-angiogenic efficacy of unprocessed MSCs-conditioned medium is low, and insufficient for tissue repair. Autophagy is a process for protein recycling and a contributor for cell exocrine, which may enhance pro-angiogenic efficacy of the conditioned medium by stimulating cytokine release from UCMSCs. Therefore, in this study we attempted to obtain enhanced autophagy in UCMSCs using different concentrations of rapamycin and compared pro-angiogenic functions of the conditioned media. The

Indexed as

AngiogenesisAutophagyConditioned mediumUmbilical cord mesenchymal stem cells

Identifiers

PMID38053620

DOI10.1016/j.bbrep.2023.101583

PMCPMC10694647

OpenAlexW4388793440

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.