Evidence map›Paper›PMID 38053478›Full record

Trial reportNeuropsychopharmacology reports2024

Effects of bilateral repetitive transcranial magnetic stimulation on prospective memory in patients with schizophrenia: A double-blind randomized controlled clinical trial.

Fen Xue, Xin-Fu Wang, Fan-Ni Kong, Tian-Lu Yin, Yu-Hong Wang, Li-Da Shi, Xiao-Wen Liu, Hui-Jing Yu, Li-Jun Liu, Ping Zhu and 4 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Neuropsychopharmacology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Fen XueMental Health Hospital, Dongcheng district, Beijing, Chaci community, China.
Xin-Fu WangRong Jun Hospital, Hebei Province, Baoding, Lianchi District, China.
Fan-Ni KongNational Institute on Drug Dependence and Beijing Key laboratory of Drug Dependence Research, Peking University, Beijing, Haidian District, China.
Tian-Lu YinInstitute of Medical Information, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Yu-Hong WangRong Jun Hospital, Hebei Province, Baoding, Lianchi District, China.
Li-Da ShiRong Jun Hospital, Hebei Province, Baoding, Lianchi District, China.
Xiao-Wen LiuRong Jun Hospital, Hebei Province, Baoding, Lianchi District, China.
Hui-Jing YuRong Jun Hospital, Hebei Province, Baoding, Lianchi District, China.
Li-Jun LiuRong Jun Hospital, Hebei Province, Baoding, Lianchi District, China.
Ping ZhuMental Health Hospital, Dongcheng district, Beijing, Chaci community, China.
Xiao-Xue QiMental Health Hospital, Dongcheng district, Beijing, Chaci community, China.
Xue-Jing XuCollege of Education, Temple University, Philadelphia, Pennsylvania, USA.
Hong-Pu HuInstitute of Medical Information, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Su-Xia LiNational Institute on Drug Dependence and Beijing Key laboratory of Drug Dependence Research, Peking University, Beijing, Haidian District, China.ORCID https://orcid.org/0000-0002-0781-0300

Funding

Health Commission of Dongcheng District, BeijingNational Clinical Research Centre for Mental Disorder (Peking University Sixth Hospital), the key research project of independent exploration in 2021 NCRC2021Z03National Natural Science Foundation of China 81871071Natural Science Foundation of Beijing Municipality 7222109
6 · The paper itself

Abstract

aimsTo investigate effects of repetitive transcranial magnetic stimulation (rTMS) on the prospective memory (PM) in patients with schizophrenia (SCZ).

methodsFifty of 71 patients completed this double-blind placebo-controlled randomized trial and compared with 18 healthy controls' (HCs) PM outcomes. Bilateral 20 Hz rTMS to the dorsolateral prefrontal cortex at 90% RMT administered 5 weekdays for 4 weeks for a total of 20 treatments. The Positive and Negative Symptom Scale (PANSS), the Scale for the Assessment of Negative Symptoms (SANS), and PM test were assessed before and after treatment.

resultsBoth Event-based PM (EBPM) and Time-based PM (TBPM) scores at baseline were significantly lower in patients with SCZ than that in HCs. After rTMS treatments, the scores of EBPM in patients with SCZ was significantly improved and had no differences from that in HCs, while the scores of TBPM did not improved. The negative symptom scores on PANSS and the scores of almost all subscales and total scores of SANS were significantly improved in both groups.

conclusionsOur findings indicated that bilateral high-frequency rTMS treatment can alleviate EBPM but not TBPM in patients with SCZ, as well as improve the negative symptoms. SIGNIFICANCE: Our results provide one therapeutic option for PM in patients with SCZ.

Indexed as

Memory, EpisodicSchizophreniaHumansPrefrontal CortexTranscranial Magnetic StimulationTreatment Outcomecognitive functiondorsolateral prefrontal cortexevent-based prospective memorynegative symptomspositive symptomsprefrontal cortexprospective memoryrTMSschizophreniatime-based prospective memory

Identifiers

PMID38053478
PMCPMC10932802

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.