Evidence map›Paper›PMID 38053460›Full record

ArticleRMD open2023

Cardiovascular disease risk in patients with inflammatory arthritis nowadays still substantially elevated.

Reinder Raadsen, Romy Hansildaar, Lianne C Pouw, Femke Hooijberg, Laura Boekel, Gerrit Jan Wolbink, Arno W R van Kuijk, Michael T Nurmohamed

Open access · goldAbstract read
In one paragraph

Article in RMD open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Why cardio-rheumatology?European heart journal. Cardiovascular pharmacotherapy · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Reinder RaadsenAmsterdam Rheumatology and Immunology Center, Amsterdam, Noord-Holland, The Netherlands.ORCID 0000-0003-2715-5603
Romy HansildaarAmsterdam Rheumatology and Immunology Center, Amsterdam, Noord-Holland, The Netherlands.
Lianne C PouwVrije Universiteit Amsterdam Faculteit der Betawetenschappen, Amsterdam, Noord-Holland, The Netherlands.
Femke HooijbergAmsterdam Rheumatology and Immunology Center, Amsterdam, Noord-Holland, The Netherlands.
Laura BoekelAmsterdam Rheumatology and Immunology Center, Amsterdam, Noord-Holland, The Netherlands.ORCID 0000-0001-5473-7786
Gerrit Jan WolbinkAmsterdam Rheumatology and Immunology Center, Amsterdam, Noord-Holland, The Netherlands.
Arno W R van KuijkAmsterdam Rheumatology and Immunology Center, Amsterdam, Noord-Holland, The Netherlands.
Michael T NurmohamedAmsterdam Rheumatology and Immunology Center, Amsterdam, Noord-Holland, The Netherlands m.nurmohamed@reade.nl.ORCID 0000-0002-6274-1934
Amsterdam UMC Location Vrije Universiteit Amsterdam · NLVrije Universiteit Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aims to assess current cardiovascular disease risk and prevalence of risk factors in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondyloarthritis (SpA).

methods2050 consecutive patients with inflammatory arthritis (IA) and 939 controls were included, with 1308 patients with RA, 356 patients with PsA and 386 patients with SpA. In a prospective cohort setting, questionnaires regarding previous cardiovascular events and risk factors were used to assess cardiovascular risk and prevalence in patients with IA by calculating ORs using logistic regression models.

results'Traditional' cardiovascular (CV) risk factors were significantly elevated in patients with IA compared with controls. Cardiovascular disease (CVD) ORs were increased in patients with RA and PsA compared with controls, 1.61 (95% CI: 1.04 to 2.48) and 2.12 (95% CI: 1.23 to 3.66), respectively, and a trend towards increased odds was observed in patients with SpA (OR 1.43; 95% CI: 0.79 to 2.59). After adjusting for traditional risk factors, CV risk was not increased in patients with RA (OR; 0.95, 95% CI: 0.58 to 1.55), PsA (OR 1.19; 95% CI: 0.64 to 2.22) and SpA (OR; 0.91, 95% CI: 0.47 to 1.77).

conclusionCVD is currently still more prevalent in patients with IA compared with healthy controls and, more importantly, this elevated risk is highly influenced by an increased prevalence of 'traditional' CV risk factors. More attention to, as well as improvements in, identification and treatment of 'traditional' risk factors, need to be made for not only RA, but other IA conditions as well.

Indexed as

Arthritis, PsoriaticArthritis, RheumatoidCardiovascular DiseasesHumansProspective StudiesRisk Factorsarthritis, psoriaticcardiovascular diseasesrheumatoid arthritisspondylitis, ankylosing

Identifiers

PMID38053460
PMCPMC10693884
OpenAlexW4389219483

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.