ArticleRMD open2023
Still's disease continuum from childhood to elderly: data from the international AIDA Network Still's disease registry.
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Article in RMD open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- The EULAR points to consider regarding the development of criteria for the assessment of the disease activity in adult-onset Still's disease.EULAR rheumatology open · 2026Article
- Comparative evaluation of disease activity measures for adult-onset Still's disease: a multicentre, retrospective, cohort study.RMD open · 2026Article
- Pathogenic and genetic landscape of Still's disease across ages, with new insights into age-related IL-18 patterns.Arthritis research & therapy · 2026Review
- Article
- Application of machine learning techniques to explore the occurrence of macrophage activation syndrome in Still's disease: results from the GIRRCS AOSD Study Group and the AIDA Network Still's Disease Registry.Frontiers in immunology · 2026Observational
- Fever of unknown origin (FUO) FADOI-SIMIT Italian registry: can demographics, comorbidities, and clinical variables predict the etiology of classic FUO?-a prospective Italian study.Internal and emergency medicine · 2025Observational
- Unmet needs and research gaps in Still's disease across ages: proceedings from a pediatric and adult joint expert panel.Pediatric rheumatology online journal · 2025Article
- Non-Classical Complications of Adult-Onset Still's Disease: A Multicenter Spanish Study.Journal of clinical medicine · 2025Article
- Advancing multidisciplinary management of pediatric hyperinflammatory disorders.Frontiers in pediatrics · 2025Review
- EULAR and PReS bridge the age gap in Still's disease.Nature reviews. Rheumatology · 2025Article
- Still's Disease Onset in Older Adults: Clinical Features, Diagnosis, and Management.Drugs & aging · 2024Review
- Recent advances and evolving concepts in Still's disease.Nature reviews. Rheumatology · 2024Review
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Authors and funding
76 authors at 20 institutions in 12 countries.
Antonio Vitale *Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy cantariniluca@hotmail.com vitale.reumatologia@gmail.com.
Valeria Caggiano *Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.
Giuseppe LopalcoDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J) Policlinic Hospital, University of Bari, Bari, Italy.
Henrique A Mayrink GiardiniRheumatology Division, Faculdade de Medicina, Hospital das Clínicas, Universidade de Sao Paulo, Sao Paulo, Brazil.ORCID 0000-0002-0860-0882
Francesco CicciaDepartment of Precision Medicine, Università degli Studi della Campania Luigi Vanvitelli, Napoli, Italy.ORCID 0000-0002-9352-1264
Ibrahim A AlmaghlouthRheumatology Unit, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Piero RuscittiRheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, Università degli Studi dell'Aquila, L'Aquila, Italy.ORCID 0000-0003-3487-8551
Petros P SfikakisJoint Academic Rheumatology Program, Medical School, National and Kapodistrian, University of Athens, Athens, Greece.
Abdurrahman TufanDepartment of Internal Medicine, Division of Rheumatology, Gazi University, Ankara, Turkey.ORCID 0000-0001-6244-9362
Lorenzo DagnaDivision of Immunology, Transplants and Infectious Diseases, Università Vita-Salute San Raffaele, Milan, Italy.ORCID 0000-0002-7428-315X
Roberto GiacomelliClinical and research section of Rheumatology and Clinical Immunology, Fondazione Policlinico Campus Bio-Medico, Rome, Italy.
Andrea Hinojosa-AzaolaDepartment of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición, Mexico City, Mexico.
Gafaar RagabInternal Medicine Department, Rheumatology and Clinical Immunology Unit, Cairo University, Giza, Egypt.
Haner DireskeneliDepartment of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey.ORCID 0000-0003-2598-5806
Lampros FotisDepartment of Pediatrics, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Jurgen SotaDepartment of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.
Florenzo IannoneDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J) Policlinic Hospital, University of Bari, Bari, Italy.
Maria MorroneDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J) Policlinic Hospital, University of Bari, Bari, Italy.
Isabele Parente de Brito AntonelliRheumatology Division, Faculdade de Medicina, Hospital das Clínicas, Universidade de Sao Paulo, Sao Paulo, Brazil.
Marilia Ambiel DagostinRheumatology Division, Faculdade de Medicina, Hospital das Clínicas, Universidade de Sao Paulo, Sao Paulo, Brazil.
Daniela IaconoDepartment of Precision Medicine, Università degli Studi della Campania Luigi Vanvitelli, Napoli, Italy.
Martina PatroneDepartment of Precision Medicine, Università degli Studi della Campania Luigi Vanvitelli, Napoli, Italy.
Kazi AsfinaCollege of Medicine Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.ORCID 0000-0002-3453-3660
Fehaid AlanaziRheumatology Unit, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Ilenia Di ColaRheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, Università degli Studi dell'Aquila, L'Aquila, Italy.
Carla GaggianoDepartment of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.ORCID 0000-0003-1401-8343
Maria G TektonidouJoint Academic Rheumatology Program, Medical School, National and Kapodistrian, University of Athens, Athens, Greece.ORCID 0000-0003-2238-0975
Riza Can KardasDepartment of Internal Medicine, Division of Rheumatology, Gazi University, Ankara, Turkey.
Hamit KucukDepartment of Internal Medicine, Division of Rheumatology, Gazi University, Ankara, Turkey.
Corrado CampochiaroDivision of Immunology, Transplants and Infectious Diseases, Università Vita-Salute San Raffaele, Milan, Italy.ORCID 0000-0001-6806-3794
Alessandro TomelleriDivision of Immunology, Transplants and Infectious Diseases, Università Vita-Salute San Raffaele, Milan, Italy.ORCID 0000-0002-5440-2078
Luca NavariniClinical and research section of Rheumatology and Clinical Immunology, Fondazione Policlinico Campus Bio-Medico, Rome, Italy.ORCID 0000-0001-8537-1510
Onorina BerardicurtiClinical and research section of Rheumatology and Clinical Immunology, Fondazione Policlinico Campus Bio-Medico, Rome, Italy.
Eduardo Martín-NaresDepartment of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición, Mexico City, Mexico.ORCID 0000-0002-7911-1269
Jiram Torres-RuizDepartment of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición, Mexico City, Mexico.
Ayman Abdel-Monem Ahmed MahmoudInternal Medicine Department, Rheumatology and Clinical Immunology Unit, Cairo University, Giza, Egypt.
Fatma Alibaz-OnerDepartment of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey.ORCID 0000-0002-6653-1758
Katerina KourtesiDepartment of Pediatrics, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Maria TarsiaAzienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Azienda Ospedaliero-Universitaria Senese, Siena, Italy.
Paolo SfrisoRheumatology Unit, Department of Medicine, University of Padua, Padua, Italy.ORCID 0000-0001-6432-7174
Joanna MakowskaDepartment of Rheumatology, Medical University of Lodz, Lodz, Poland.
Marcello GovoniRheumatology Unit, Department of Medical Sciences, Azienda Ospedaliero-Universitaria S. Anna-Ferrara, University of Ferrara, Ferrara, Italy.
Francesco La TorreDepartment of Pediatrics, Pediatric Rheumatology Center, Giovanni XXIII Pediatric Hospital, University of Bari Aldo Moro, Bari, Italy.
Maria Cristina MaggioUniversity Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE) "G. D'Alessandro", University of Palermo, Palermo, Italy.
Sara MontiDepartment of Internal Medicine and Therapeutics, University of Pavia; early Arthritis Clinic, IRCCS Policlinico S. Matteo Foundation, Pavia, Italy.ORCID 0000-0002-1800-6772
Emanuela Del GiudicePediatric and Neonatology Unit, Department of Maternal Infantile and Urological Sciences, University of Rome La Sapienza, Rome, Italy.
Giacomo EmmiDepartment of Experimental and Clinical Medicine, University of Florence, Firenze, Italy.ORCID 0000-0001-9575-8321
Elena BartoloniRheumatology Unit, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.ORCID 0000-0003-4776-2136
José Hernández-RodríguezDepartment of Autoimmune Diseases, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Hospital Clínic of Barcelona [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], University of Barcelona, Barcelona, Spain.
Verónica Gómez-CaverzaschiDepartment of Autoimmune Diseases, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Hospital Clínic of Barcelona [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], University of Barcelona, Barcelona, Spain.
Armin MaierRheumatology Unit, Department of Medicine, Central Hospital of Bolzano, Bolzano, Italy.
Gabriele SimoniniNEUROFARBA Department, Rheumatology Unit, Meyer Children's Hospital IRCCS, University of Florence, Firenze, Italy.
Annamaria IagnoccoAcademic Rheumatology Centre, Dipartimento Scienze Cliniche e Biologiche, Università degli Studi di Torino, Torino, Italy.
Giovanni ContiPediatric Nephrology and Rheumatology Unit, Azienda Ospedaliera Universitaria (AOU), "G. Martino", Messina, Italy.
Alma Nunzia OlivieriDepartment of Woman, Child and of General and Specialized Surgery, University of Campania Luigi Vanvitelli, Napoli, Italy.
Amato De PaulisDepartment of Translational Medical Sciences, Section of Clinical Immunology, University of Naples Federico II, Napoli, Italy.
Alberto Lo GulloUnit of Rheumatology, Department of Medicine, ARNAS Garibaldi Hospital, Catania, Italy.ORCID 0000-0003-4383-0314
Ombretta ViapianaRheumatology Unit, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.ORCID 0000-0003-1917-5655
Ewa Wiesik-SzewczykDepartment of Internal Medicine, Pneumonology, Allergology and Clinical Immunology, Central Clinical Hospital of the Ministry of National Defense, Poland Ministry of Interior and Administration, Warszawa, Poland.
Sukran ErtenDepartment of Rheumatology, Faculty of Medicine Ankara City Hospital, Ankara Yildirim Beyazit Universitesi, Ankara, Turkey.
Benson OgunjimiDepartment of Paediatrics, University Hospital Antwerp, Edegem, Belgium.
Francesco CarubbiDepartment of Life, Health & Environmental Sciences and Internal Medicine and Nephrology Unit, Department of Medicine, University of L'Aquila and ASL Avezzano-Sulmona-L'Aquila, San Salvatore Hospital, L'Aquila, Italy.ORCID 0000-0003-1958-5136
Samar TharwatRheumatology and Immunology Unit, Internal Medicine Department, Mansoura University, Mansoura, Egypt.
Katerina LaskariJoint Academic Rheumatology Program, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Stefania CostiDepartment of Clinical Sciences and Community Health, Research Center for Adult and Pediatric Rheumatic Diseases, University of Milan, Milano, Italy.
Paola TriggianeseRheumatology, Allergology and Clinical Immunology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Anastasios KaramanakosJoint Academic Rheumatology Program, First Department of Propaedeutic and Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Alessandro ConfortiU.O.Medicina Generale, Ospedale San Paolo di Civitavecchia, ASL Roma 4, Civitavecchia, Rome, Italy.
Micol FrassiRheumatology and Clinical Immunology, Spedali Civili and Department of Clinical and Experimental Sciences, [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], University of Brescia, Brescia, Italy.
Gian Domenico SebastianiUOC di Reumatologia, Azienda Ospedaliera San Camillo Forlanini, Roma, Italy.
Antonio GidaroDepartment of Biomedical and Clinical Sciences Luigi Sacco, Luigi Sacco Hospital, University of Milan, Milan, Italy.
Angela MauroPediatric Unit, Fatebenefratelli Hospital, Milan, Milan.
Alberto BalistreriBioengineering and Biomedical Data Science Lab, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Claudia FabianiAzienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Azienda Ospedaliero-Universitaria Senese, Siena, Italy.
Bruno FredianiDepartment of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.
Luca CantariniDepartment of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy cantariniluca@hotmail.com vitale.reumatologia@gmail.com.ORCID 0000-0002-7352-1275
University of Siena · ITNational and Kapodistrian University of Athens · GRUniversity of Campania "Luigi Vanvitelli" · ITGazi University · TRHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán · MXKing Saud University · SAUniversità Campus Bio-Medico · ITUniversity of Bari Aldo Moro · ITUniversity of L'Aquila · ITVita-Salute San Raffaele University · ITCairo University · EGConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESMarmara University · TRUniversity of Milan · ITAnkara Yıldırım Beyazıt University · TRASL Roma · ITAzienda Ospedaliera San Camillo-Forlanini · ITAzienda Ospedaliera Universitaria Integrata Verona · ITAzienda Ospedaliera Universitaria Policlinico "G. Martino" · IT
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveStill's disease is more frequently observed in the paediatric context, but a delayed onset is not exceptional both in the adulthood and in the elderly. However, whether paediatric-onset, adult-onset and elderly-onset Still's disease represent expressions of the same disease continuum or different clinical entities is still a matter of controversy. The aim of this study is to search for any differences in demographic, clinical features and response to treatment between pediatric-onset, adult-onset and elderly-onset Still's disease.
methodsSubjects included in this study were drawn from the International AutoInflammatory Disease Alliance Network registry for patients with Still's disease.
resultsA total of 411 patients suffering from Still's disease were enrolled; the disease occurred in the childhood in 65 (15.8%) patients, in the adult 314 (76.4%) patients and in the elderly in 32 (7.8%) patients. No statistically significant differences at post-hoc analysis were observed in demographic features of the disease between pediatric-onset, adult-onset and elderly-onset Still's disease. The salmon-coloured skin rash (p=0.004), arthritis (p=0.009) and abdominal pain (p=0.007) resulted significantly more frequent among paediatric patients than in adult cases, while pleuritis (p=0.015) and arthralgia (p<0.0001) were significantly more frequent among elderly-onset patients compared with paediatric-onset subjects. Regarding laboratory data, thrombocytosis was significantly more frequent among paediatric patients onset compared with adult-onset subjects (p<0.0001), while thrombocytopenia was more frequent among elderly-onset patients although statistical significance was only bordered. No substantial differences were observed in the response to treatments.
conclusionsDespite some minor difference between groups, overall, demographic, clinical, laboratory and treatments aspects of Still's disease were similarly observed in patients at all ages. This supports that pediatric-onset, adult-onset and elderly-onset Still's disease is the same clinical condition arising in different ages.
Indexed as
Arthritis, JuvenileStill's Disease, Adult-OnsetAdultAgedArthralgiaChildHumansChildEpidemiologyStill's Disease, Adult-Onset
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