Evidence map›Paper›PMID 38053456›Full record

Observational studyRMD open2023

Association between hyperuricaemia and hand osteoarthritis: data from the Xiangya Osteoarthritis Study.

Yanqiu Zhu, Jiatian Li, Yuqing Zhang, Weiya Zhang, Michael Doherty, Zidan Yang, Yang Cui, Chao Zeng, Guanghua Lei, Tuo Yang and 1 more

Registry-linked trialOpen access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in RMD open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04033757 (A Population-based Cohort of Osteoarthritis), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04033757 active not recruitingnot on this map

A Population-based Cohort of Osteoarthritis: the Xiangya Osteoarthritis Study

Typeobservational_patient_registrySponsorXiangya Hospital of Central South UniversityRan2015 to 2031Enrolled4,080ConditionsOsteoarthritis
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Yanqiu Zhu *Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China.
Jiatian Li *Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.
Yuqing ZhangDivision of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0001-7638-0888
Weiya ZhangAcademic Rheumatology, School of Medicine, University of Nottingham, Nottingham, UK.
Michael DohertyAcademic Rheumatology, School of Medicine, University of Nottingham, Nottingham, UK.
Zidan YangKey Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China.
Yang CuiXiangya International Medical Center, Xiangya Hospital, Central South University, Changsha, China.
Chao ZengDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China.
Guanghua LeiDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.ORCID 0000-0003-2987-138X
Tuo YangAcademic Rheumatology, School of Medicine, University of Nottingham, Nottingham, UK weij1988@csu.edu.cn yangtuo@csu.edu.cn.
Jie WeiDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China weij1988@csu.edu.cn yangtuo@csu.edu.cn.ORCID 0000-0003-3510-8241
Central South University · CNUniversity of Nottingham · GBHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe pathogenesis of hand osteoarthritis (OA) remains unknown. Hyperuricaemia, which is related to inflammation, may play a role in hand OA, but evidence is lacking. In a large population-based study, we examined the association between hyperuricaemia and hand OA.

methodsParticipants were from the Xiangya OA Study, a community-based observational study. Hyperuricaemia was defined as serum urate >416 µmol/L in men and >357 µmol/L in women. Radiographic hand OA (RHOA) was defined as presence of the modified Kellgren-Lawrence grade ≥2 in any hand joint. Symptomatic hand OA (SHOA) was defined as presence of both self-reported symptoms and RHOA in the same hand. The associations of hyperuricaemia with RHOA or SHOA were examined using generalised estimating equations.

resultsAmong 3628 participants, the prevalence of RHOA was higher in participants with hyperuricaemia than those with normouricaemia (26.9% vs 20.9%), with an adjusted OR (aOR) of 1.34 (95% CI 1.11 to 1.61). The associations were consistent in men (aOR 1.33, 95% CI 1.01 to 1.74) and women (aOR 1.35, 95% CI 1.05 to 1.74). Hyperuricaemia was mainly associated with bilateral RHOA (aOR 1.54, 95% CI 1.18 to 2.01) but not unilateral RHOA (aOR 1.13, 95% CI 0.89 to 1.45). Prevalence of SHOA was higher, although statistically insignificant, in participants with hyperuricaemia (aOR 1.39, 95% CI 0.94 to 2.07).

conclusionIn this population-based study, hyperuricaemia was associated with a higher prevalence of hand OA. Future prospective studies are required to investigate the temporal relationship. TRIAL REGISTRATION NUMBER: NCT04033757.

Indexed as

Hand JointsHyperuricemiaOsteoarthritisFemaleHandHumansMaleProspective Studiesarthritisepidemiologyosteoarthritis

Identifiers

PMID38053456
PMCPMC10693871
OpenAlexW4389219669

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.