ArticleMolecular therapy : the journal of the American Society of Gene Therapy2024
TLR9-independent CD8
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Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 24 citations in OpenAlex.
- Clinical immunogenicity in rAAV gene therapy: Insights and implications.Molecular therapy. Advances · 2026Review
- Nanoparticles targeting liver sinusoidal endothelial cells improve tolerance to vector and transgene antigens through tolerance spreading.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Long-term restoration of auditory function in a DFNA2 mouse model by adenine base editing.EMBO molecular medicine · 2026Article
- Deaths in gene therapy of Duchenne muscular dystrophy and other diseases: Underlying mechanisms and mitigating strategies.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Review
- Mechanisms of and mitigating strategies for cellular immune responses to CRISPR-associated nucleases in genome editing therapy.Frontiers in medicine · 2026Review
- Intelligent design of tumor microenvironment-responsive Adeno-associated virus vectors: overcoming delivery barriers and enabling precision therapy.Medical oncology (Northwood, London, England) · 2025Review
- Can Sex-based Variations in the Immune Responses to AAV Gene Therapy Affect Safety and Efficacy? A Review of Current Understanding.The AAPS journal · 2025Review
- Toll-Like Receptors in the Immunotherapy Era: Dual-Edged Swords of Tumor Immunity and Clinical Translation.MedComm · 2025Review
- Novel Immune Response Evasion Strategy to Redose Adeno-associated Viral Vectors and Prolong Survival in Surfactant Protein-B-Deficient Mice.American journal of respiratory cell and molecular biology · 2025Article
- Inhibition of IFNAR-JAK signaling enhances tolerability and transgene expression of systemic non-viral DNA delivery.Molecular therapy. Nucleic acids · 2025Article
- Investigating the Immunogenic Potential of Variations in Host Cell Protein Levels in Clinical-Grade AAV8 Products.Investigative ophthalmology & visual science · 2025Article
- The deLIVERed promises of gene therapy: Past, present, and future of liver-directed gene therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Review
- Gene therapy for hemophilia - From basic science to first approvals of "one-and-done" therapies.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Review
- The curious case of AAV immunology.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Review
- AAV vectors trigger DNA damage response-dependent pro-inflammatory signalling in human iPSC-derived CNS models and mouse brain.Nature communications · 2025Article
- Targeting PSMB5-induced PANoptosis in bladder cancer: multi-omics insights and TCM candidate discovery.Frontiers in immunology · 2025Article
- Redundancy in Innate Immune Pathways That Promote CD8Viruses · 2024Article
- Viral Vector Based Immunotherapy for Peanut Allergy.Viruses · 2024Review
- Innate Immune Sensing of Adeno-Associated Virus Vectors.Human gene therapy · 2024Review
- Role of FoxP3Human gene therapy · 2024Review
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 2 countries.
Sandeep R P KumarDepartment of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University, Indianapolis, IN, USA.
Moanaro BiswasDepartment of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University, Indianapolis, IN, USA.
Di CaoDepartment of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University, Indianapolis, IN, USA.
Sreevani ArisaDepartment of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University, Indianapolis, IN, USA.
Maite Muñoz-MeleroDepartment of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University, Indianapolis, IN, USA.
Anh K LamDepartment of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University, Indianapolis, IN, USA.
Annie R PiñerosDepartment of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University, Indianapolis, IN, USA.
Reuben KapurDepartment of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University, Indianapolis, IN, USA.
Tsuneyasu KaishoDepartment of Immunology, Institute of Advanced Medicine, Wakayama Medical University, Wakayama, Japan.
Randal J KaufmanCenter for Genetic Disorders and Aging Research, Samford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Weidong XiaoDepartment of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University, Indianapolis, IN, USA.
Dmitry M ShayakhmetovLowance Center for Human Immunology, Emory Vaccine Center, Departments of Pediatrics and Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Cox TerhorstDivision of Immunology, Beth Israel Deaconess Medical Center (BIDMC), Boston, MA, USA.
Ype P de JongDivision of Gastroenterology & Hepatology, Weill Cornell Medicine, New York, NY, USA.
Roland W HerzogDepartment of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University, Indianapolis, IN, USA. Electronic address: rwherzog@iu.edu.
Indiana University – Purdue University Indianapolis · USBeth Israel Deaconess Medical Center · USCornell University · USDiscovery Institute · USEmory University · USWakayama Medical University · JP
Funding
Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Sara K Quinney · 1999 to 2026
$59.3MToward Safer Gene Therapy for Hemophilia AP01HL160472 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI Roland W. Herzog · 2022 to 2026
$15.1MProject-005U54DK106846 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Reuben Kapur, Karen Elizabeth Pollok · 2015 to 2026
$9.7MEnhancing immune regulation in gene therapy for hemophiliaR01HL131093 · NHLBI · UNIVERSITY OF FLORIDA · PI Ype Peter De Jong, Roland W. Herzog · 2016 to 2026
$7.2MImmunology of Factor IX Gene Transfer to LiverR01AI051390 · NIAID · UNIVERSITY OF FLORIDA · PI HERZOG, ROLAND W. · 2002 to 2022
$6.7MMechanisms of adenovirus neutralizationR01AI107960 · NIAID · EMORY UNIVERSITY · PI SHAYAKHMETOV, DMITRY, STEWART, PHOEBE L · 2014 to 2024
$6.5MRole of p21 activated kinase in LeukemogenesisR01CA173852 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI KAPUR, REUBEN · 2014 to 2025
$3.4MMechanistic factors limiting utility of adenovirus vectors for treatment of neoplaR01CA267694 · NCI · EMORY UNIVERSITY · PI Dmitry Shayakhmetov · 2022 to 2026
$3.1MMolecular mechanisms of adenovirus neutralizationR37AI107960 · NIAID · EMORY UNIVERSITY · PI PHOEBE L STEWART, Dmitry Shayakhmetov · 2026 to 2026
$806kBD FACSAria SystemS10OD012270 · OD · INDIANA UNIVERSITY INDIANAPOLIS · PI SROUR, EDWARD F · 2013 to 2013
$516kNCI NIH HHS P30 CA082709NCI NIH HHS R01 CA173852NCI NIH HHS R01 CA267694NHLBI NIH HHS P01 HL160472NHLBI NIH HHS R01 HL131093NIAID NIH HHS R01 AI051390NIAID NIH HHS R37 AI107960NIDDK NIH HHS U54 DK106846NIH HHS S10 OD012270
Abstract
Upon viral infection of the liver, CD8
Indexed as
CD8-Positive T-LymphocytesMyeloid Differentiation Factor 88AnimalsCapsid ProteinsDendritic CellsInterleukin-1LiverMiceToll-Like Receptor 9Capsid ProteinsInterleukin-1Myeloid Differentiation Factor 88Tlr9 protein, mouseToll-Like Receptor 9AAVCD8(+) T cellIL-1IL-1 receptorinnate immunityKupffer cellliver gene therapyplasmacytoid dendritic cellToll-like receptor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.