Evidence map›Paper›PMID 38053245›Full record

ArticleThe International journal of artificial organs2024

Cardiogenic shock etiology and exit strategy impact survival in patients with Impella 5.5.

McKenzie Sicke, Shan Modi, Yeahwa Hong, Michael Bashline, Wyatt Klass, Ed Horn, Barinder S Hansra, Raj Ramanan, Jeffrey Fowler, Nikita Sumzin and 7 more

Abstract read
In one paragraph

Article in The International journal of artificial organs, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

McKenzie SickeUniversity of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.ORCID 0009-0009-3500-5489
Shan ModiDepartment of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Yeahwa HongDepartment of Surgery, University of Pittsburgh Medical Center Health System, Pittsburgh, PA, USA.
Michael BashlineDivision of Cardiology Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.ORCID 0000-0001-6686-8978
Wyatt KlassDivision of Cardiology Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Ed HornDepartment of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA.
Barinder S HansraDepartment of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Raj RamananDepartment of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.ORCID 0000-0002-1970-2964
Jeffrey FowlerDivision of Cardiology Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Nikita SumzinDepartment of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Ryan M RivosecchiDepartment of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA.
Rahul ChaudharyDivision of Cardiology Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Luke A ZieglerDivision of Cardiology Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Nicholas R HessDepartment of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA USA.
Nishant AgrawalUniversity of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
David J KaczorowskiDepartment of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA USA.
Gavin W HickeyDivision of Cardiology Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Funding

Training Program in Imaging Sciences in Translational Cardiovascular ResearchT32HL129964 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Flordeliza S Villanueva · 2016 to 2026
$4.7M
NHLBI NIH HHS T32 HL129964
6 · The paper itself

Abstract

backgroundDespite historical differences in cardiogenic shock (CS) outcomes by etiology, outcomes by CS etiology have yet to be described in patients supported by temporary mechanical circulatory support (MCS) with Impella 5.5.

objectivesThis study aims to identify differences in survival and post-support destination for these patients in acute myocardial infarction (AMI) and acute decompensated heart failure (ADHF) CS at a high-volume, tertiary, transplant center.

methodsA retrospective review of patients who received Impella 5.5 at our center from November 2020 to June 2022 was conducted.

resultsSixty-seven patients underwent Impella 5.5 implantation for CS; 23 (34%) for AMI and 44 (66%) for ADHF. AMI patients presented with higher SCAI stage, pre-implant lactate, and rate of prior MCS devices, and fewer days from admission to implantation. Survival was lower for AMI patients at 30 days, 90 days, and discharge. No difference in time to all-cause mortality was found when excluding patients receiving transplant. There was no significant difference in complication rates between groups.

conclusionsADHF-CS patients with Impella 5.5 support have a significantly higher rate of survival than patients with AMI-CS. ADHF patients were successfully bridged to heart transplant more often than AMI patients, contributing to increased survival.

Indexed as

Heart-Assist DevicesHeart FailureMyocardial InfarctionHumansRetrospective StudiesShock, CardiogenicTreatment Outcomeacute heart failureheart transplantMechanical circulatory support

Identifiers

PMID38053245
PMCPMC10824236

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.