ArticleClinical epigenetics2023
Epigenetics of the far northern Yakutian population.
Article in Clinical epigenetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- DNA methylation-predicted protein differences between Yakutian and Central Russian populations.Epigenomics · 2025Article
- Age-Related Human Adaptation to Extreme Climatic Factors and Environmental Conditions.Biology · 2025Article
- What's counted counts: the implications of underrepresentation for the application of epigenetic clocks in diverse populations.Clinical epigenetics · 2025Review
- EpInflammAge: Epigenetic-Inflammatory Clock for Disease-Associated Biological Aging Based on Deep Learning.International journal of molecular sciences · 2025Article
- Inflammaging Markers in the Extremely Cold Climate: A Case Study of Yakutian Population.International journal of molecular sciences · 2024Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
backgroundYakuts are one of the indigenous populations of the subarctic and arctic territories of Siberia characterized by a continental subarctic climate with severe winters, with the regular January average temperature in the regional capital city of Yakutsk dipping below - 40 °C. The epigenetic mechanisms of adaptation to such ecologies and environments and, in particular, epigenetic age acceleration in the local population have not been studied before.
resultsThis work reports the first epigenetic study of the Yakutian population using whole-blood DNA methylation data, supplemented with the comparison to the residents of Central Russia. Gene set enrichment analysis revealed, among others, geographic region-specific differentially methylated regions associated with adaptation to climatic conditions (water consumption, digestive system regulation), aging processes (actin filament activity, cell fate), and both of them (channel activity, regulation of steroid and corticosteroid hormone secretion). Further, it is demonstrated that the epigenetic age acceleration of the Yakutian representatives is significantly higher than that of Central Russia counterparts. For both geographic regions, we showed that epigenetically males age faster than females, whereas no significant sex differences were found between the regions.
conclusionsWe performed the first study of the epigenetic data of the Yakutia cohort, paying special attention to region-specific features, aging processes, age acceleration, and sex specificity.
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