Evidence map›Paper›PMID 38053125›Full record

ArticleEuropean journal of medical research2023

Low HDL-C can be a biomarker to predict persistent severe AKI in septic patients? A retrospective cohort study.

Wei Jiang, Lin Song, Weilei Gong, Yaosheng Zhang, Kerang Shi, Ting Liao, Chuanqing Zhang, Jiangquan Yu, Ruiqiang Zheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Wei Jiang *Medical College, Yangzhou University, Yangzhou, 225001, China.
Lin Song *Medical College, Yangzhou University, Yangzhou, 225001, China.
Weilei GongSchool of Pharmaceutical Sciences and Institute of Materia Medica, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250000, China.
Yaosheng Zhang *School of Clinical and Basic Medicine, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250000, China.
Kerang ShiMedical College, Yangzhou University, Yangzhou, 225001, China.
Ting LiaoMedical College, Yangzhou University, Yangzhou, 225001, China.
Chuanqing ZhangMedical College, Yangzhou University, Yangzhou, 225001, China.
Jiangquan YuDepartment of Critical Care Medicine, Clinical Medicine College, Yangzhou University and Intensive Care Unit, Northern Jiangsu People's Hospital, Yangzhou, 225001, China. yujiangquan2013@163.com.
Ruiqiang ZhengDepartment of Critical Care Medicine, Clinical Medicine College, Yangzhou University and Intensive Care Unit, Northern Jiangsu People's Hospital, Yangzhou, 225001, China. zhengruiqiang2021@163.com.
Northern Jiangsu People's Hospital · CNShandong First Medical University · CNYangzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposesLow HDL-C is associated with an increased risk of sepsis-associated AKI and subsequent decline in eGFR. HDL-C possesses anti-inflammatory, antioxidant, and endothelial repair-promoting properties. The use of Apo A-I mimetic peptides, which are the main structural components of HDL-C, has been shown to improve renal function in animal models of sepsis. However, the diagnostic value of low HDL-C in persistent sepsis-associated AKI remains unclear.

methodsThis is a retrospective cohort study based on MIMIC IV (V 2.2). The study population consisted of all adult septic patients admitted to the Beth Israel Deaconess Medical Center Intensive Care Unit from 2008 to 2019, with plasma HDL-C measured within 24 h of ICU admission. The primary endpoint was persistent severe sepsis-associated acute kidney injury (SA-AKI) and the secondary endpoint is kidney replacement therapy (KRT). Logistic regression was used to assess the correlation between HDL-C and persistent severe SA-AKI and KRT, and receiver operating characteristic (ROC) curve analysis was performed to evaluate predictive ability.

resultsA total of 604 cases of SA-AKI patients were included in the analysis, among which 88 cases (14.5%) experienced persistent severe SA-AKI. The median (IQR) HDL-C level in the group with persistent severe SA-AKI was lower (33.0 [24.0-45.5]) compared to the non-persistent severe SA-AKI group (42.0 [31.0-53.0]). However, HDL-C showed poor discriminatory ability with an AUROC [95%CI] of 0.62 [0.56-0.69]. Clinical prediction models based on serum creatinine concentration, 24-h creatinine change, APSIIIscore, lactate levels, APTT, and heart rate performed well in predicting persistent severe SA-AKI with an AUROC [95%CI] of 0.876 [0.84-0.91]. However, adding HDL-C to this model did not improve predictive performance.

conclusionsThe plasma HDL-C measured within 24 h after admission to the ICU does not provide a good prediction for persistent severe SA-AKI, and it does not improve the clinical predictive ability compared to conventional variables.

Indexed as

Acute Kidney InjurySepsisAdultBiomarkersCreatinineHumansIntensive Care UnitsRetrospective StudiesROC CurveBiomarkersCreatinineHigh-density lipoprotein cholesterolLipoproteinsPersistent acute kidney injurySepsis

Identifiers

PMID38053125
PMCPMC10696658
OpenAlexW4389342145

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.