Evidence map›Paper›PMID 38053039›Full record

ArticleBMC nephrology2023

Fibronectin glomerulopathy in a kidney allograft biopsy.

Nathaniel Klair, Salman B Mahmood, Rasha El-Rifai, Cynthia C Nast, Lihong Bu, Adam Bregman

Open access · goldAbstract readCase Reports
In one paragraph

Article in BMC nephrology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. [Glomerulopathy with fibronectin deposits caused byZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Nathaniel KlairDepartment of Internal Medicine, University of Minnesota Medical Center, Minneapolis, MN, USA.
Salman B MahmoodDivision of Nephrology and Hypertension, Department of Medicine, University of Minnesota Medical Center, 717 Delaware St SE, Minneapolis, MN, 55414, USA.
Rasha El-RifaiDivision of Nephrology and Hypertension, Department of Medicine, University of Minnesota Medical Center, 717 Delaware St SE, Minneapolis, MN, 55414, USA.
Cynthia C NastDepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Lihong Bu *Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Adam Bregman *Division of Nephrology and Hypertension, Department of Medicine, University of Minnesota Medical Center, 717 Delaware St SE, Minneapolis, MN, 55414, USA. bregm006@umn.edu.
University of Minnesota Medical Center · USCedars-Sinai Medical Center · USMayo Clinic in Arizona · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFibronectin glomerulopathy is a rare genetic nephropathy with only a few cases of post-transplant recurrence being reported previously. We highlight a case that was initially misdiagnosed and emphasize the importance of full immunofluorescence and electron microscopy evaluation in allograft biopsies. CASE PRESENTATION: A 36-year-old male with a history of end-stage kidney disease secondary to biopsy-proven type 1 membranoproliferative glomerulonephritis (MPGN) status-post living unrelated donor kidney transplant 12 years prior, presented with increasing creatinine and proteinuria. Biopsy was performed and was consistent with fibronectin glomerulopathy. Subsequent genetic testing revealed an FN1 mutation, the primary gene associated with this condition.

conclusionsFull histologic evaluation of the allograft biopsy corrected the diagnosis and additionally suggested that the patient's mother, who had expired in her 30s and had received a diagnosis of type 1 MPGN on autopsy, likely also had fibronectin glomerulopathy, enabling appropriate genetic counseling for the family.

Indexed as

Glomerulonephritis, MembranoproliferativeAdultAllograftsBiopsyFemaleHumansKidneyMaleNeoplasm Recurrence, LocalFibronectin glomerulopathyFN1 mutationKidney biopsy

Identifiers

PMID38053039
PMCPMC10696822
OpenAlexW4389338958

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.