Evidence map›Paper›PMID 38052982›Full record

SynthesisMolecular psychiatry2024

Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence.

Priyanka Choudhary, Giulietta S Monasso, Ville Karhunen, Justiina Ronkainen, Giulia Mancano, Caitlin G Howe, Zhongzheng Niu, Xuehuo Zeng, Weihua Guan, John Dou and 84 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Molecular psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Article
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  6. Article
  7. Review
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  9. Article
  10. Ketamine and its enantiomers for depression: a bibliometric analysis from 2000 to 2023.European archives of psychiatry and clinical neuroscience · 2025
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

94 authors.

Priyanka Choudhary *Research Unit of Population Health, Faculty of Medicine, University of Oulu, 90014, Oulu, Finland. Priyanka.Choudhary@oulu.fi.ORCID 0000-0002-2420-4118
Giulietta S Monasso *The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Ville KarhunenResearch Unit of Population Health, Faculty of Medicine, University of Oulu, 90014, Oulu, Finland.ORCID 0000-0001-6064-1588
Justiina RonkainenResearch Unit of Population Health, Faculty of Medicine, University of Oulu, 90014, Oulu, Finland.
Giulia MancanoMedical Research Council Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK.
Caitlin G HoweDepartment of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA.ORCID 0000-0002-4935-9298
Zhongzheng NiuDepartment of Population and Public Health Sciences, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Xuehuo ZengGlotech, Inc., Rockville, MD, 20850, USA.
Weihua GuanDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, 55455, USA.
John DouDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Jason I FeinbergDepartment of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MA, USA.ORCID 0000-0002-6556-3635
Charles MordauntDepartment of Medical Micriobiology and Immunology, University of California Davis, Davis, CA, USA.
Giancarlo PesceEpidemiology of Allergic and Respiratory Diseases (EPAR) team, Faculté de Médecine Saint-Antoine, Institute Pierre Louis d'Epidemiologie et Sante Publique (IPLESP), Sorbonne Université and INSERM, Paris, France.ORCID 0000-0003-4925-6325
Nour BaïzInstitute Desbrest of Epidemiology and Public Health, University of Montpellier and INSERM, Montpellier, France.
Rossella AlfanoCentre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium.
Dries S MartensCentre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium.
Congrong WangCentre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium.
Elena IsaevskaCancer Epidemiology Unit, Department of Medical Sciences, University of Turin and CPO-Piemonte, Torino, Italy.
Elina KeikkalaDepartment of Obstetrics and Gynaecology, Research Unit of Clinical Medicine, Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland.
Sanna MustaniemiDepartment of Obstetrics and Gynaecology, Research Unit of Clinical Medicine, Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland.
Chris H L ThioDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Eliza FraszczykDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Elmar W TobiDepartment of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC, University Medical Center, 3000 CA, Rotterdam, the Netherlands.
Anne P StarlingDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Marta Cosin-TomasISGlobal (Barcelona Institute for Global Health), Barcelona Biomedical Research Park (PRBB), Doctor Aiguader, 88, 08003, Barcelona, Spain.ORCID 0000-0001-5012-8983
Jose UrquizaISGlobal (Barcelona Institute for Global Health), Barcelona Biomedical Research Park (PRBB), Doctor Aiguader, 88, 08003, Barcelona, Spain.
Stefan RöderDepartment for Environmental Immunology, Helmholtz Centre for Environmental Research, UFZ, Leipzig, Germany.ORCID 0000-0001-9367-663X
Thanh T HoangEpidemiology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.ORCID 0000-0002-8498-0020
Christian PageCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Dereje D JimaCenter for Human Health and the Environment, North Carolina State University, Raleigh, NC, 27606, USA.ORCID 0000-0002-7784-1612
John S HouseCenter for Human Health and the Environment, North Carolina State University, Raleigh, NC, 27606, USA.ORCID 0000-0002-8447-7871
Rachel L MaguireDepartment of Biological Sciences, North Carolina State University, Raleigh, NC, USA.
Raffael OttInstitute of Diabetes Research, Helmholtz Munich, German Research Center for Environmental Health, Munich, Germany.
Xenia PawlowInstitute of Diabetes Research, Helmholtz Munich, German Research Center for Environmental Health, Munich, Germany.
Lea SirignanoDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID 0000-0002-7989-5833
Lea ZillichDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID 0000-0001-7457-374X
Anni MalmbergDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Sebastian RauschertTelethon Kids Institute, Perth, WA, Australia.
Phillip MeltonMenzies Institute of Medical Research, University of Tasmania, Hobart, TAS, Australia.ORCID 0000-0003-4026-2964
Tong GongDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Robert KarlssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-8949-2587
Ruby ForeDivision of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Wei PerngDepartment of Epidemiology and the Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Zachary M LaubachDepartment of Ecology and Evolutionary Biology, University of Colorado Boulder, Boulder, CO, USA.
Darina CzamaraDepartment Genes and Environment, Max Planck Institute for Psychiatry, Kraepelinstrasse 2+10, 80804, Munich, Germany.ORCID 0000-0001-7381-904X
Gemma SharpMedical Research Council Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK.
Carrie V BretonDepartment of Population and Public Health Sciences, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Enrique SchistermanDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Edwina YeungEpidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, 20817, USA.
Sunni L MumfordDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
M Daniele FallinDepartment of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MA, USA.
Janine M LaSalleDepartment of Medical Micriobiology and Immunology, University of California Davis, Davis, CA, USA.ORCID 0000-0002-3480-2031
Rebecca J SchmidtDepartment of Public Health Sciences, School of Medicine, University of California Davis (UC Davis), Davis, CA, USA.ORCID 0000-0003-1582-2747
Kelly M BakulskiDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-9605-6337
Isabella Annesi-MaesanoInstitute Desbrest of Epidemiology and Public Health, University of Montpellier and INSERM, Montpellier, France.ORCID 0000-0002-6340-9300
Barbara HeudeUniversité de Paris Cité, Inserm, INRAE, Centre of Research in Epidemiology and StatisticS (CRESS), F-75004, Paris, France.ORCID 0000-0002-1565-1629
Tim S NawrotCentre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium.
Michelle PlusquinCentre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium.
Akram GhantousEpigenomics and Mechanisms Branch, International Agency for Research on Cancer, Lyon, France.
Zdenko HercegEpigenomics and Mechanisms Branch, International Agency for Research on Cancer, Lyon, France.
Lorenza NisticòCentre for Behavioural Sciences and Mental Health, Istituto Superiore di Sanità, Viale Regina Elena, Rome, Italy.
Marina VafeiadiDepartment of Social Medicine, School of Medicine, University of Crete, Heraklion, Crete, Greece.ORCID 0000-0002-6143-7172
Manolis KogevinasBarcelona Institute for Global Health (ISGlobal), Barcelona, Spain.
Marja VääräsmäkiDepartment of Obstetrics and Gynaecology, Research Unit of Clinical Medicine, Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland.
Eero KajantieFinnish Institute for Health and Welfare, Population Health Unit, Public Health and Welfare, Helsinki and Oulu, Finland.
Harold SniederDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0003-1949-2298
Eva CorpeleijnDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Regine P M Steegers-TheunissenDepartment of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC, University Medical Center, 3000 CA, Rotterdam, the Netherlands.
Ivana V YangDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Dana DabeleaDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Serena FossatiISGlobal (Barcelona Institute for Global Health), Barcelona Biomedical Research Park (PRBB), Doctor Aiguader, 88, 08003, Barcelona, Spain.
Ana C ZenclussenDepartment for Environmental Immunology, Helmholtz Centre for Environmental Research, UFZ, Leipzig, Germany.
Gunda HerberthDepartment for Environmental Immunology, Helmholtz Centre for Environmental Research, UFZ, Leipzig, Germany.ORCID 0000-0003-0212-3509
Maria MagnusCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Siri E HåbergCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Stephanie J LondonEpidemiology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.ORCID 0000-0003-4911-5290
Monica Cheng Munthe-KaasDepartment of Pediatrics, Oncology and Hematology, Oslo University Hospital, Oslo, Norway.
Susan K MurphyDepartment of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, 27701, USA.ORCID 0000-0001-8298-7272
Cathrine HoyoCenter for Human Health and the Environment, North Carolina State University, Raleigh, NC, 27606, USA.
Anette-G ZieglerInstitute of Diabetes Research, Helmholtz Munich, German Research Center for Environmental Health, Munich, Germany.
Sandra HummelInstitute of Diabetes Research, Helmholtz Munich, German Research Center for Environmental Health, Munich, Germany.
Stephanie H WittDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID 0000-0002-1571-1468
Fabian StreitDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID 0000-0003-1080-4339
Josef FrankDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID 0000-0003-4867-9465
Katri RäikkönenDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Jari LahtiDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-4310-5297
Rae-Chi HuangTelethon Kids Institute, Perth, WA, Australia.
Catarina AlmqvistDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Marie-France HivertDivision of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.ORCID 0000-0001-7752-2585
Vincent W V JaddoeThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.ORCID 0000-0003-2939-0041
Marjo-Riitta JärvelinResearch Unit of Population Health, Faculty of Medicine, University of Oulu, 90014, Oulu, Finland.ORCID 0000-0002-2149-0630
Marko KantomaaResearch Unit of Population Health, Faculty of Medicine, University of Oulu, 90014, Oulu, Finland.
Janine F FelixThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.ORCID 0000-0002-9801-5774
Sylvain SebertResearch Unit of Population Health, Faculty of Medicine, University of Oulu, 90014, Oulu, Finland.ORCID 0000-0001-6681-6983

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3M
Translational Research Support CoreP30ES025128 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Sue Fenton · 2015 to 2026
$18.3M
Genetic And Environmental Factors In Childhood Respiratory HealthZIAES049019 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE · 2009 to 2025
$6.8M
Upstate KIDS Follow-Up StudyZIAHD008949 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI YEUNG, EDWINA · 2015 to 2025
$4.8M
Duke University Program in Environmental HealthT32ES021432 · NIEHS · DUKE UNIVERSITY · PI Akhenaton-Andrew Dhafir Jones, Joel Newman Meyer · 2013 to 2026
$4.0M
Prenatal exposure to metals and risk for Autism Spectrum Disorder in MARBLES and EARLIR01ES025531 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI VOLK, HEATHER E · 2016 to 2020
$3.2M
Follow-up and Maintenance of the Newborn Epigenetics STudy (NEST) CohortR24ES028531 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI HOYO, CATHRINE, MURPHY, SUSAN KAY · 2018 to 2022
$1.9M
BUILDS MARBLES: Biorepository Upkeep and Infrastructure for Longitudinal Data Sharing for MARBLESU24ES028533 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHAMBERS BUTCHER, BRITTANY D., SCHMIDT, REBECCA JEAN · 2023 to 2025
$1.2M
Prenatal Metal Mixtures, Fetal Growth, and the Role of MicroRNAsR00ES030400 · NIEHS · DARTMOUTH COLLEGE · PI HOWE, CAITLIN GRACE · 2020 to 2022
$726k
EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) 733206EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) 848158EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) 873749Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P30 ES025128NIEHS NIH HHS R00 ES030400NIEHS NIH HHS R01 ES025531NIEHS NIH HHS R24 ES028531NIEHS NIH HHS T32 ES021432NIEHS NIH HHS U24 ES028533World Health Organization 001
6 · The paper itself

Abstract

Maternal educational attainment (MEA) shapes offspring health through multiple potential pathways. Differential DNA methylation may provide a mechanistic understanding of these long-term associations. We aimed to quantify the associations of MEA with offspring DNA methylation levels at birth, in childhood and in adolescence. Using 37 studies from high-income countries, we performed meta-analysis of epigenome-wide association studies (EWAS) to quantify the associations of completed years of MEA at the time of pregnancy with offspring DNA methylation levels at birth (n = 9 881), in childhood (n = 2 017), and adolescence (n = 2 740), adjusting for relevant covariates. MEA was found to be associated with DNA methylation at 473 cytosine-phosphate-guanine sites at birth, one in childhood, and four in adolescence. We observed enrichment for findings from previous EWAS on maternal folate, vitamin-B

Indexed as

DNA MethylationEducational StatusEpigenesis, GeneticEpigenomeGenome-Wide Association StudyAcademic SuccessAdolescentAdultChildChild, PreschoolFemaleHumansInfantInfant, NewbornMaleMothers

Identifiers

PMID38052982
PMCPMC11116099

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