ArticleMolecular psychiatry2024
Sleep spindle architecture associated with distinct clinical phenotypes in older adults at risk for dementia.
Article in Molecular psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Sleep spindle density increases in patients with severe obstructive sleep apnea after 6 months of treatment: a longitudinal study.Scientific reports · 2026Article
- Late-stage interventional trials reporting sleep-related outcomes in older adults with Parkinson's disease: a ClinicalTrials.gov registry review.BMC geriatrics · 2026Review
- Long-term forgetting, sleep, and tau in autosomal-dominant Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Nightly variations in sleep quality and next-day cognitive performance: an in-home study in healthy older adults.Frontiers in aging neuroscience · 2026Article
- Sleep spindles are linked to white matter connectivity differentially in older adults with and without cognitive impairment.Brain communications · 2026Article
- Sleep Spindle Abnormalities as Neurophysiological Biomarkers of Schizophrenia Spectrum Disorders: From Cellular Mechanisms and Neural Circuits to Clinical Implications.Biological psychiatry · 2025Review
- Sleep disturbances and disorders in the memory clinic: Self-report, actigraphy, and polysomnography.Journal of Alzheimer's disease : JAD · 2025Article
- Threshold Values of Sleep Spindles Features in Healthy Adults Using Scalp-EEG and Associations With Sleep Parameters.Annals of clinical and translational neurology · 2025Observational
- Article
- Differential expression of spatiotemporal sleep spindle clusters in aging.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Noradrenergic therapies in neurodegenerative disease: from symptomatic to disease modifying therapy?Brain communications · 2025Review
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Sleep spindles are a hallmark of non-REM sleep and play a fundamental role in memory consolidation. Alterations in these spindles are emerging as sensitive biomarkers for neurodegenerative diseases of ageing. Understanding the clinical presentations associated with spindle alterations may help to elucidate the functional role of these distinct electroencephalographic oscillations and the pathophysiology of sleep and neurodegenerative disorders. Here, we use a data-driven approach to examine the sleep, memory and default mode network connectivity phenotypes associated with sleep spindle architecture in older adults (mean age = 66 years). Participants were recruited from a specialist clinic for early diagnosis and intervention for cognitive decline, with a proportion showing mild cognitive deficits on neuropsychological testing. In a sample of 88 people who underwent memory assessment, overnight polysomnography and resting-state fMRI, a k-means cluster analysis was applied to spindle measures of interest: fast spindle density, spindle duration and spindle amplitude. This resulted in three clusters, characterised by preserved spindle architecture with higher fast spindle density and longer spindle duration (Cluster 1), and alterations in spindle architecture (Clusters 2 and 3). These clusters were further characterised by reduced memory (Clusters 2 and 3) and nocturnal hypoxemia, associated with sleep apnea (Cluster 3). Resting-state fMRI analysis confirmed that default mode connectivity was related to spindle architecture, although directionality of this relationship differed across the cluster groups. Together, these results confirm a diversity in spindle architecture in older adults, associated with clinically meaningful phenotypes, including memory function and sleep apnea. They suggest that resting-state default mode connectivity during the awake state can be associated with sleep spindle architecture; however, this is highly dependent on clinical phenotype. Establishing relationships between clinical and neuroimaging features and sleep spindle alterations will advance our understanding of the bidirectional relationships between sleep changes and neurodegenerative diseases of ageing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.