ArticleNature chemistry2024
Azobenzene as a photoswitchable mechanophore.
Article in Nature chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 131 citations in OpenAlex.
- Dynamic Biomaterial: A Platform for Biomedical Applications With Multiple Preparation Strategies.Macromolecular rapid communications · 2026Review
- Divinylazobenzene-Q-Cage Silyloxy-Silsesquioxane-Based Reversible Photoactuatable Network Polymer Sponges.Macromolecules · 2026Article
- Force Reveals Hidden Conformations and Dissociation Pathways in Individual π-Interacting Dimers.Angewandte Chemie (International ed. in English) · 2026Article
- γ-Ray Regulated Host-Guest Molecular Recognition.Angewandte Chemie (International ed. in English) · 2026Article
- Organic Cation Conformation-Modulated Dimensionality in Chiral Metal Halides for Enhancing Linear and Nonlinear Chiroptical Properties.Angewandte Chemie (International ed. in English) · 2026Article
- Tailored Nanogel Network Topology Enables Clinical Ultrasound-Induced Mechanochemical Activation for In Vivo Therapy.Angewandte Chemie (International ed. in English) · 2026Article
- Modeling Targeted Mechanochemistry in Polymeric Solids.Chemical reviews · 2026Review
- Highly sensitive X-ray responsive molecular switches.Nature communications · 2026Article
- Mechanochemical and machine-intelligent design of programmable materials: From molecular interactions to macroscale functionality.Materials today. Bio · 2026Review
- Viscoelastic Hydrogels Governed by Molecular Interactions and Mechanochemical Effects.Polymers · 2026Review
- Bioinspired Microphase-Engineered Binders for Silicon Anodes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Recent Advances of Azobenzene-Based Photoresponsive Molecular Switches for Protein-Targeted Photopharmacology.Molecules (Basel, Switzerland) · 2026Review
- Ultrasound-driven mechanophore activation in living plants.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Multi-responsive upconversion/organic porous silicon nanocomposite for controlled drug releaseRSC advances · 2026Article
- Cycloreversion-enhanced toughness and degradability in mechanophore-embedded end-linked polymer networks.Nature communications · 2026Article
- High-Throughput Discovery of Ferrocene Mechanophores with Enhanced Reactivity and Network Toughening.ACS central science · 2025Article
- Force-Triggered Thermodynamically Uphill Disulfide Reduction through Sulfur Oxidation State Control.Journal of the American Chemical Society · 2025Article
- Optical Force Monitoring in Polymeric Materials with a Coumarin-Based Mechanophore.Angewandte Chemie (International ed. in English) · 2025Article
- Computational Exploration of Polymer Mechanochemistry: Quantitation of Activation Force and Systematic Discovery of Reaction Sites by the Extended Artificial Force-Induced Reaction Method.Journal of the American Chemical Society · 2025Article
- Near-infrared light-activatedChemical science · 2025Article
Corrections and comments
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Authors and funding
18 authors at 5 institutions in 2 countries.
Funding
Abstract
Azobenzene has been widely explored as a photoresponsive element in materials science. Although some studies have investigated the force-induced isomerization of azobenzene, the effect of force on the rupture of azobenzene has not been explored. Here we show that the light-induced structural change of azobenzene can also alter its rupture forces, making it an ideal light-responsive mechanophore. Using single-molecule force spectroscopy and ultrasonication, we found that cis and trans para-azobenzene isomers possess contrasting mechanical properties. Dynamic force spectroscopy experiments and quantum-chemical calculations in which azobenzene regioisomers were pulled from different directions revealed that the distinct rupture forces of the two isomers are due to the pulling direction rather than the energetic difference between the two isomers. These mechanical features of azobenzene can be used to rationally control the macroscopic fracture behaviours of polymer networks by photoillumination. The use of light-induced conformational changes to alter the mechanical response of mechanophores provides an attractive way to engineer polymer networks of light-regulatable mechanical properties.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.