Evidence map›Paper›PMID 38052887›Full record

ArticleSurgical endoscopy2024

Laparoscopic and open minor liver resection for hepatocellular carcinoma with clinically significant portal hypertension: a multicenter study using inverse probability weighting approach.

Hiroji Shinkawa, Masaki Kaibori, Daijiro Kabata, Takuya Nakai, Masaki Ueno, Daisuke Hokuto, Hisashi Ikoma, Hiroya Iida, Koji Komeda, Shogo Tanaka and 9 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Surgical endoscopy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 9 institutions in 1 country.

Hiroji ShinkawaDepartment of Hepatobiliary-Pancreatic Surgery, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-0051, Japan. hirojishinkawa9876@gmail.com.ORCID 0000-0002-0164-2414
Masaki KaiboriDepartment of Surgery, Hirakata Hospital, Kansai Medical University, Hirakata, Osaka, Japan.
Daijiro KabataDepartment of Medical Statistics, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Takuya NakaiDepartment of Surgery, Faculty of Medicine, Kindai University, Osakasayama, Osaka, Japan.
Masaki UenoSecond Department of Surgery, Wakayama Medical University, Wakayama, Japan.
Daisuke HokutoDepartment of Surgery, Nara Medical University, Kashihara, Nara, Japan.
Hisashi IkomaDivision of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Hiroya IidaDepartment of Surgery, Shiga University of Medical Science, Otsu, Shiga Prefecture, Japan.
Koji KomedaDepartment of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan.
Shogo TanakaDepartment of Hepatobiliary-Pancreatic Surgery, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-0051, Japan.
Hisashi KosakaDepartment of Surgery, Hirakata Hospital, Kansai Medical University, Hirakata, Osaka, Japan.
Chihoko NoboriDepartment of Surgery, Faculty of Medicine, Kindai University, Osakasayama, Osaka, Japan.
Shinya HayamiSecond Department of Surgery, Wakayama Medical University, Wakayama, Japan.
Satoshi YasudaDepartment of Surgery, Nara Medical University, Kashihara, Nara, Japan.
Ryo MorimuraDivision of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Haruki MoriDepartment of Surgery, Shiga University of Medical Science, Otsu, Shiga Prefecture, Japan.
Shuji KagotaDepartment of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan.
Shoji KuboDepartment of Hepatobiliary-Pancreatic Surgery, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-0051, Japan.
Takeaki IshizawaDepartment of Hepatobiliary-Pancreatic Surgery, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-0051, Japan.
Osaka Metropolitan University · JPKansai Medical University · JPKindai University · JPKyoto Prefectural University of Medicine · JPNara Medical University · JPOsaka University of Pharmaceutical Sciences · JPShiga University of Medical Science · JPWakayama Medical University · JPOsaka City University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLiver resection offers substantial advantages over open liver resection (OLR) for patients with hepatocellular carcinoma (HCC) in terms of reduced intraoperative blood loss and morbidity. However, there is limited evidence comparing the indications and perioperative outcomes with the open versus laparoscopic approach for resection. This study aimed to compare postoperative outcomes between patients undergoing laparoscopic liver resection (LLR) and OLR for HCC with clinically significant portal hypertension (CSPH).

methodsA total of 316 HCC patients with CSPH (the presence of gastroesophageal varices or platelet count < 100,000/ml and spleen diameter > 12 cm) undergoing minor liver resection at eight centers were included in this study. To adjust for confounding factors between the LLR and OLR groups, an inverse probability weighting method analysis was performed.

resultsOverall, 193 patients underwent LLR and 123 underwent OLR. After weighting, LLR was associated with a lower volume of intraoperative blood loss and the incidence of postoperative complications (including pulmonary complications, incisional surgical site infection, and paralytic ileus) compared to the OLR group. The 3-, 5-, and 7-year postoperative recurrence-free survival rates were 39%, 26%, and 22% in the LLR group and 49%, 18%, and 18% in the OLR group, respectively (p = 0.18). And, the 3-, 5-, and 7-year postoperative overall survival rates were 71%, 56%, and 44% in the LLR group and 76%, 51%, 44% in the OLR group, respectively (p = 0.87).

conclusionsLLR for HCC patients with CSPH is clinically advantageous by lowering the volume of intraoperative blood loss and incidence of postoperative complications, thereby offering feasible long-term survival.

Indexed as

Carcinoma, HepatocellularHypertension, PortalLaparoscopyLiver NeoplasmsBlood Loss, SurgicalHepatectomyHumansLength of StayPostoperative ComplicationsPropensity ScoreRetrospective StudiesSurgical Wound InfectionHepatocellular carcinomaLaparoscopic liver resectionPortal hypertension

Identifiers

PMID38052887
OpenAlexW4389333400

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.