Evidence map›Paper›PMID 38052861›Full record

ArticlePediatric research2024

Associations between human milk oligosaccharides and infant growth in a Bangladeshi mother-infant cohort.

Miranda G Loutet, Arash Narimani, Huma Qamar, Chloe Yonemitsu, Lisa G Pell, Abdullah Al Mahmud, Tahmeed Ahmed, Lars Bode, Diego G Bassani, Daniel E Roth

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Miranda G LoutetThe Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada. miranda.loutet@sickkids.ca.
Arash NarimaniThe Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Huma QamarThe Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Chloe YonemitsuUniversity of California San Diego, San Diego, CA, USA.
Lisa G PellThe Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Abdullah Al MahmudNutrition and Clinical Services Division, icddr,b, Dhaka, Bangladesh.
Tahmeed AhmedNutrition and Clinical Services Division, icddr,b, Dhaka, Bangladesh.
Lars BodeUniversity of California San Diego, San Diego, CA, USA.
Diego G BassaniThe Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Daniel E RothThe Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Hospital for Sick Children · CAInternational Centre for Diarrhoeal Disease Research · BDUniversity of California San Diego · US

Funding

Bill and Melinda Gates Foundation
6 · The paper itself

Abstract

backgroundWe aimed to estimate associations between human milk oligosaccharides (HMOs) and infant growth (length-for-age (LAZ) and weight-for-length (WLZ) z-scores) at 12 months postnatal age.

methodsIn this secondary analysis of data from a maternal vitamin D trial in Dhaka, Bangladesh (N = 192), absolute concentrations of HMOs were measured in 13 ± 1 week(s) postpartum milk samples, infant anthropometric measurements were obtained soon after birth and at 12 months postpartum, and infant feeding was classified during 6 months postpartum. Associations between individual HMOs or HMO groups and LAZ or WLZ were estimated by multivariable linear regression adjusting for infant feeding pattern, maternal secretor status, and other potential confounders.

resultsThe concentrations of 6'sialyllactose, lacto-N-neotetraose, and the non-fucosylated non-sialylated HMOs were inversely associated with LAZ at 12 months of age, whereas the fucosylated non-sialylated HMO concentration was positively associated with LAZ at 12 months. These associations were robust in analyses restricted to infants who were primarily exclusively/predominantly fed human milk during the first 3 (or 6) months.

conclusionsSince HMOs are both positively and negatively associated with postnatal growth, there is a need for randomized trials to estimate the causal benefits and risks of exogenously administered HMOs on infant growth and other health outcomes. IMPACT: 6'sialyllactose, lacto-N-neotetraose, and the non-fucosylated non-sialylated human milk oligosaccharides (HMOs) were inversely associated with length-for-age z-scores (LAZ) at 12 months, whereas the fucosylated non-sialylated HMO concentration was positively associated with LAZ at 12 months among Bangladeshi infants. Associations between individual and grouped HMOs with infant length growth at 12 months were as strong or stronger in analyses restricted to infants who were exclusively or predominantly fed human milk up to 3 (or 6) months. Randomized trials are needed to characterize the effects of specific HMOs on infant growth, particularly in countries where postnatal linear growth faltering is common.

Indexed as

Child DevelopmentMilk, HumanOligosaccharidesAdultBangladeshBody HeightBody WeightBreast FeedingCohort StudiesFemaleHumansInfantInfant, NewbornLactoseMale6'-sialyllactoselacto-N-neotetraoseLactoseOligosaccharides

Identifiers

PMID38052861
PMCPMC11343707
OpenAlexW4389329663

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.