Evidence map›Paper›PMID 38052849›Full record

ArticleScientific reports2023

Quantitative biodistribution of nanoparticles in plants with lanthanide complexes.

H Hou, Z Xu, Y S Takeda, M Powers, Y Yang, K Hershberger, Hailey Hanscom, S Svenson, R K Simhadri, A J Vegas

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

H Hou *Division of Materials Science and Engineering, Boston University, Boston, MA, USA.
Z Xu *Department of Chemistry, Boston University, Boston, MA, USA.
Y S TakedaInvaio Sciences, Cambridge, MA, USA.
M PowersInvaio Sciences, Cambridge, MA, USA.
Y YangInvaio Sciences, Cambridge, MA, USA.
K HershbergerInvaio Sciences, Cambridge, MA, USA.
Hailey HanscomInvaio Sciences, Cambridge, MA, USA.
S SvensonInvaio Sciences, Cambridge, MA, USA.
R K SimhadriInvaio Sciences, Cambridge, MA, USA.
A J VegasDivision of Materials Science and Engineering, Boston University, Boston, MA, USA. ajvegas@bu.edu.
Boston University · US

Funding

Invaio Science SRA
6 · The paper itself

Abstract

The inefficient distribution of fertilizers, nutrients, and pesticides on crops is a major challenge in modern agriculture that leads to reduced productivity and environmental pollution. Nanoformulation of agrochemicals is an attractive approach to enable the selective delivery of agents into specific plant organs, their release in those tissues, and improve their efficiency. Already commercialized nanofertilizers utilize the physiochemical properties of metal nanoparticles such as size, charge, and the metal core to overcome biological barriers in plants to reach their target sites. Despite their wide application in human diseases, lipid nanoparticles are rarely used in agricultural applications and a systematic screening approach to identifying efficacious formulations has not been reported. Here, we developed a quantitative metal-encoded platform to determine the biodistribution of different lipid nanoparticles in plant tissues. In this platform lanthanide metal complexes were encapsulated into four types of lipid nanoparticles. Our approach was able to successfully quantify payload accumulation for all the lipid formulations across the roots, stem, and leaf of the plant. Lanthanide levels were 20- to 57-fold higher in the leaf and 100- to 10,000-fold higher in the stem for the nanoparticle encapsulated lanthanide complexes compared to the unencapsulated, free lanthanide complex. This system will facilitate the discovery of nanoparticles as delivery carriers for agrochemicals and plant tissue-targeting products.

Indexed as

Metal NanoparticlesNanoparticlesAgricultureAgrochemicalsCrops, AgriculturalFertilizersHumansMetalsTissue DistributionAgrochemicalsFertilizersMetals

Identifiers

PMID38052849
PMCPMC10698154
OpenAlexW4389338823

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.