Evidence map›Paper›PMID 38052825›Full record

ArticleNature communications2023

Functional divergence of a bacterial enzyme promotes healthy or acneic skin.

Irshad A Hajam, Madhusudhanarao Katiki, Randall McNally, María Lázaro-Díez, Stacey Kolar, Avradip Chatterjee, Cesia Gonzalez, Mousumi Paulchakrabarti, Biswa Choudhury, J R Caldera and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
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  9. A novelFrontiers in microbiology · 2025
    Article
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  14. Structures ofmicroPublication biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Irshad A Hajam *Department of Pediatrics, University of California San Diego, San Diego, CA, 92093, USA.
Madhusudhanarao Katiki *Department of Biomedical Sciences, Research Division of Immunology, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.
Randall McNally *Department of Biomedical Sciences, Research Division of Immunology, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.
María Lázaro-Díez *Department of Pediatrics, University of California San Diego, San Diego, CA, 92093, USA.ORCID 0000-0002-6098-8052
Stacey Kolar *Department of Biomedical Sciences, Research Division of Immunology, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.
Avradip ChatterjeeDepartment of Biomedical Sciences, Research Division of Immunology, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.ORCID 0000-0001-8345-4339
Cesia GonzalezDepartment of Pediatrics, University of California San Diego, San Diego, CA, 92093, USA.
Mousumi PaulchakrabartiGlycoAnalytics Core, University of California San Diego, San Diego, CA, 92093, USA.
Biswa ChoudhuryGlycoAnalytics Core, University of California San Diego, San Diego, CA, 92093, USA.
J R CalderaDepartment of Pediatrics, University of California San Diego, San Diego, CA, 92093, USA.ORCID 0000-0003-0563-8815
Trieu DesmondDepartment of Pediatrics, University of California San Diego, San Diego, CA, 92093, USA.
Chih-Ming TsaiDepartment of Pediatrics, University of California San Diego, San Diego, CA, 92093, USA.
Xin DuDepartment of Pediatrics, University of California San Diego, San Diego, CA, 92093, USA.ORCID 0000-0002-6907-3609
Huiying LiDepartment of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90095, USA.
Ramachandran MuraliDepartment of Biomedical Sciences, Research Division of Immunology, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA. ramachandran.murali@csmc.edu.ORCID 0000-0002-8384-2793
George Y LiuDepartment of Pediatrics, University of California San Diego, San Diego, CA, 92093, USA. gyliu@health.ucsd.edu.ORCID 0000-0003-0759-0587
University of California San Diego · USCedars-Sinai Medical Center · USInstitute for Molecular Medicine · USUC San Diego Health System · USUniversity of California, San Francisco · US

Funding

Generating protective immunity to Staphylococcus aureusR01AI127406 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI LIU, GEORGE Y, MARTINS, GISLAINE A · 2017 to 2021
$2.8M
Pathogenic and protective roles of strain-specific P. acnes hyaluronidases in acneR01AI141401 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI LIU, GEORGE Y, MURALI, RAMACHANDRAN · 2019 to 2023
$2.7M
NIAID NIH HHS R01 AI127406NIAID NIH HHS R01 AI141401
6 · The paper itself

Abstract

Acne is a dermatologic disease with a strong pathologic association with human commensal Cutibacterium acnes. Conspicuously, certain C. acnes phylotypes are associated with acne, whereas others are associated with healthy skin. Here we investigate if the evolution of a C. acnes enzyme contributes to health or acne. Two hyaluronidase variants exclusively expressed by C. acnes strains, HylA and HylB, demonstrate remarkable clinical correlation with acne or health. We show that HylA is strongly pro-inflammatory, and HylB is modestly anti-inflammatory in a murine (female) acne model. Structural and phylogenic studies suggest that the enzymes evolved from a common hyaluronidase that acquired distinct enzymatic activity. Health-associated HylB degrades hyaluronic acid (HA) exclusively to HA disaccharides leading to reduced inflammation, whereas HylA generates large-sized HA fragments that drive robust TLR2-dependent pathology. Replacing an amino acid, Serine to Glycine near the HylA catalytic site enhances the enzymatic activity of HylA and produces an HA degradation pattern intermediate to HylA and HylB. Selective targeting of HylA using peptide vaccine or inhibitors alleviates acne pathology. We suggest that the functional divergence of HylA and HylB is a major driving force behind C. acnes health- and acne- phenotype and propose targeting of HylA as an approach for acne therapy.

Indexed as

Acne VulgarisHyaluronoglucosaminidaseAmino AcidsAnimalsFemaleHumansMicePropionibacterium acnesSkinAmino AcidsHyaluronoglucosaminidase

Identifiers

PMID38052825
PMCPMC10697930
OpenAlexW4389330777

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.