Evidence map›Paper›PMID 38052775›Full record

ArticleLight, science & applications2023

Submonolayer biolasers for ultrasensitive biomarker detection.

Chaoyang Gong, Xi Yang, Shui-Jing Tang, Qian-Qian Zhang, Yanqiong Wang, Yi-Ling Liu, Yu-Cheng Chen, Gang-Ding Peng, Xudong Fan, Yun-Feng Xiao and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Light, science & applications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Chaoyang Gong *Key Laboratory of Optical Fiber Sensing and Communications (Ministry of Education of China), School of Information and Communication Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan, 611731, China.
Xi Yang *Key Laboratory of Optical Fiber Sensing and Communications (Ministry of Education of China), School of Information and Communication Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan, 611731, China.
Shui-Jing Tang *State Key Laboratory for Mesoscopic Physics and Frontiers Science Centre for Nano-optoelectronics, School of Physics, Peking University, Beijing, 100871, China.ORCID http://orcid.org/0000-0003-2896-324X
Qian-Qian Zhang *Key Laboratory of Optical Fiber Sensing and Communications (Ministry of Education of China), School of Information and Communication Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan, 611731, China.
Yanqiong WangKey Laboratory of Optical Fiber Sensing and Communications (Ministry of Education of China), School of Information and Communication Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan, 611731, China.
Yi-Ling LiuKey Laboratory of Optical Fiber Sensing and Communications (Ministry of Education of China), School of Information and Communication Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan, 611731, China.
Yu-Cheng ChenSchool of Electrical and Electronic Engineering, Nanyang Technological University, Singapore, 639798, Singapore.ORCID http://orcid.org/0000-0002-0008-5601
Gang-Ding PengSchool of Electrical Engineering and Telecommunications, University of New South Wales, Sydney, NSW, 2052, Australia.
Xudong FanDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
Yun-Feng XiaoState Key Laboratory for Mesoscopic Physics and Frontiers Science Centre for Nano-optoelectronics, School of Physics, Peking University, Beijing, 100871, China. yfxiao@pku.edu.cn.ORCID http://orcid.org/0000-0002-0296-7130
Yun-Jiang RaoKey Laboratory of Optical Fiber Sensing and Communications (Ministry of Education of China), School of Information and Communication Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan, 611731, China. yjrao@uestc.edu.cn.ORCID http://orcid.org/0000-0003-0717-5586
Yuan GongKey Laboratory of Optical Fiber Sensing and Communications (Ministry of Education of China), School of Information and Communication Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan, 611731, China. ygong@uestc.edu.cn.ORCID http://orcid.org/0000-0001-6819-8402
University of Electronic Science and Technology of China · CNPeking University · CNNanyang Technological University · SGUniversity of Michigan · USUNSW Sydney · AU

Funding

National Natural Science Foundation of China (National Science Foundation of China) 62275043
6 · The paper itself

Abstract

Biomarker detection is key to identifying health risks. However, designing sensitive and single-use biosensors for early diagnosis remains a major challenge. Here, we report submonolayer lasers on optical fibers as ultrasensitive and disposable biosensors. Telecom optical fibers serve as distributed optical microcavities with high Q-factor, great repeatability, and ultralow cost, which enables whispering-gallery laser emission to detect biomarkers. It is found that the sensing performance strongly depends on the number of gain molecules. The submonolayer lasers obtained a six-order-of-magnitude improvement in the lower limit of detection (LOD) when compared to saturated monolayer lasers. We further achieve an ultrasensitive immunoassay for a Parkinson's disease biomarker, alpha-synuclein (α-syn), with a lower LOD of 0.32 pM in serum, which is three orders of magnitude lower than the α-syn concentration in the serum of Parkinson's disease patients. Our demonstration of submonolayer biolaser offers great potentials in high-throughput clinical diagnosis with ultimate sensitivity.

Identifiers

PMID38052775
PMCPMC10698069
OpenAlexW4389395832

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.