Evidence map›Paper›PMID 38052761›Full record

ArticleJournal of medical ultrasonics (2001)2024

Optimizing irradiation conditions for low-intensity pulsed ultrasound to upregulate endothelial nitric oxide synthase.

Daiki Ouchi, Shohei Mori, Mototaka Arakawa, Tomohiko Shindo, Hiroaki Shimokawa, Satoshi Yasuda, Hiroshi Kanai

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of medical ultrasonics (2001), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Daiki OuchiGraduate School of Engineering, Tohoku University, 6-6-05 Aoba, Aramaki, Aoba-Ku, Sendai, Miyagi, 980-8579, Japan.
Shohei MoriGraduate School of Engineering, Tohoku University, 6-6-05 Aoba, Aramaki, Aoba-Ku, Sendai, Miyagi, 980-8579, Japan.ORCID http://orcid.org/0000-0002-5494-1055
Mototaka ArakawaGraduate School of Engineering, Tohoku University, 6-6-05 Aoba, Aramaki, Aoba-Ku, Sendai, Miyagi, 980-8579, Japan. arakawa@tohoku.ac.jp.ORCID http://orcid.org/0000-0001-9386-645X
Tomohiko ShindoDepartment of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.ORCID http://orcid.org/0000-0003-3420-9999
Hiroaki ShimokawaDepartment of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.ORCID http://orcid.org/0000-0001-7534-4826
Satoshi YasudaDepartment of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Hiroshi KanaiGraduate School of Engineering, Tohoku University, 6-6-05 Aoba, Aramaki, Aoba-Ku, Sendai, Miyagi, 980-8579, Japan. hiroshi.kanai.e7@tohoku.ac.jp.ORCID http://orcid.org/0000-0002-6567-1687
Tohoku University · JP

Funding

Japan Society for the Promotion of Interdisciplinary Research and Development Grants-in-Aid for H-24Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (23H03753)
6 · The paper itself

Abstract

purposeHere we aimed to develop a minimally invasive treatment for ischemic heart disease and demonstrate that low-intensity pulsed ultrasound (LIPUS) therapy improves myocardial ischemia by promoting myocardial angiogenesis in a porcine model of chronic myocardial ischemia. Studies to date determined the optimal treatment conditions within the range of settings available with existing ultrasound equipment and did not investigate a wider range of conditions.

methodsWe investigated a broad range of five parameters associated with ultrasound irradiation conditions that promote expression of endothelial nitric oxide synthase (eNOS), a key molecule that promotes angiogenesis in human coronary artery endothelial cells (HCAEC).

resultsSuboptimal irradiation conditions included 1-MHz ultrasound frequency, 500-kPa sound pressure, 20-min total irradiation time, 32-48-[Formula: see text] pulse duration, and 320-[Formula: see text] pulse repetition time. Furthermore, a proposed index, [Formula: see text], calculated as the product of power and the total number of irradiation cycles applied to cells using LIPUS, uniformly revealed the experimental eNOS expression associated with the various values of five parameters under different irradiation conditions.

conclusionWe determined the suboptimal ultrasound irradiation conditions for promoting eNOS expression in HCAEC.

Indexed as

Myocardial IschemiaNitric Oxide Synthase Type IIIAnimalsEndothelial CellsHumansSwineUltrasonic WavesNitric Oxide Synthase Type IIIAngiogenesisEndothelial nitric oxide synthaseHuman coronary artery endothelial cellsLow-intensity pulsed ultrasound therapy

Identifiers

PMID38052761
OpenAlexW4389330167

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.