Evidence map›Paper›PMID 38052753›Full record

ReviewCurrent environmental health reports2023

Air Pollution and Lung Cancer: Contributions of Extracellular Vesicles as Pathogenic Mechanisms and Clinical Utility.

Jonathan González-Ruíz, Andrea A Baccarelli, David Cantu-de-Leon, Diddier Prada

Open access · hybridAbstract readReview
In one paragraph

Review in Current environmental health reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
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  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Jonathan González-RuízInstituto Nacional de Cancerología, 14080, Mexico City, Mexico.
Andrea A BaccarelliMailman School of Public Health, Department of Environmental Health Sciences, Columbia University, New York City, NY, 10032, USA.
David Cantu-de-LeonInstituto Nacional de Cancerología, 14080, Mexico City, Mexico.
Diddier PradaDepartment of Population Health Science and Policy and the Department of Environmental Medicine and Public Health, Institute for Health Equity Research, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl · (212) 241-6500, Room L2-38, New York City, NY, 10029, USA. diddier.prada@mountsinai.org.
Instituto Nacional de Cancerología · MXColumbia University · USIcahn School of Medicine at Mount Sinai · US

Funding

True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
NIH FIRST Cohort Cluster Hiring Initiative at Icahn School of Medicine at Mount SinaiU54CA267776 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Emma Katherine Tara Benn, Kirk N Campbell · 2021 to 2026
$17.4M
Extracellular vesicles in Environmental Epidemiology Studies of AgingR35ES031688 · NIEHS · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Andrea Baccarelli · 2021 to 2026
$4.6M
Blood mitochondrial DNA biomarkers of midlife cognitive decline and adverse brain imaging changes - A longitudinal investigation in the CARDIA population‐based cohort studyR01AG069120 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HOU, LIFANG, YAFFE, KRISTINE · 2020 to 2024
$4.0M
Air Particulate, Metals, and Cognitive Performance in an Aging Cohort- Roles of Circulating Extracellular Vesicles and Non-coding RNAsR01ES027747 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI SCHWARTZ, JOEL D · 2017 to 2021
$3.7M
Stress, Epigenetics and AgingR01AG058704 · NIA · EMORY UNIVERSITY · PI SHELTON, RACHEL C, SUGLIA, SHAKIRA FRANCO · 2018 to 2022
$3.4M
Circulating microRNAs in Extracellular Vesicles, Air Particulate Pollution, and Lung Function in an Aging CohortR01ES025225 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BACCARELLI, ANDREA · 2016 to 2020
$2.9M
Air Particulate Pollution and Stress: Effects and Mechanisms for Long-term Maternal Obesity RisksR01ES032242 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI COLICINO, ELENA, WU, HAOTIAN · 2020 to 2024
$2.2M
NCI NIH HHS U54 CA267776NIA NIH HHS R01 AG058704NIA NIH HHS R01 AG069120NIEHS NIH HHS P30 ES009089NIEHS NIH HHS R01 ES025225NIEHS NIH HHS R01 ES027747NIEHS NIH HHS R01 ES032242NIEHS NIH HHS R35 ES031688NIH HHS P30ES009089
6 · The paper itself

Abstract

purpose of reviewThis review addresses the pressing issue of air pollution's threat to human health, focusing on its connection to non-small cell lung cancer (NSCLC) development. The aim is to explore the role of extracellular vesicles (EVs) as potential pathogenic mechanisms in lung cancer, including NSCLC, induced by air pollutants. RECENT

findingsRecent research highlights EVs as vital mediators of intercellular communication and key contributors to cancer progression. Notably, this review emphasizes the cargo of EVs released by both cancerous and non-cancerous lung cells, shedding light on their potential role in promoting various aspects of tumor development. The review underscores the importance of comprehending the intricate interplay between air pollution, biological damage mechanisms, and EV-mediated communication during NSCLC development. Major takeaways emphasize the significance of this understanding in addressing air pollution-related lung cancer. Future research avenues are also highlighted, aiming to enhance the applicability of EVs for diagnosis and targeted therapies, ultimately mitigating the inevitable impact of air pollution on NSCLC development and treatment.

Indexed as

Air PollutantsAir PollutionCarcinoma, Non-Small-Cell LungExtracellular VesiclesLung NeoplasmsHumansAir PollutantsAir pollutionBiomarkersExtracellular vesiclesLung cancerTherapeutic targets

Identifiers

PMID38052753
PMCPMC10822800
OpenAlexW4389357066

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.