Evidence map›Paper›PMID 38052500›Full record

ReviewCold Spring Harbor perspectives in biology2024

Features, Fates, and Functions of Oligodendrocyte Precursor Cells.

Robert A Hill, Akiko Nishiyama, Ethan G Hughes

Abstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Glial Cells and Aging: From the CNS to the Cerebellum.International journal of molecular sciences · 2025
    Review
  6. Spinal Cord Injury Remyelination: Pathways to Therapies.International journal of molecular sciences · 2025
    Review
  7. The Many Lives of an Oligodendrocyte Precursor Cell.Annual review of neuroscience · 2025
    Review
  8. Article
  9. Review
  10. Transient Upregulation of Procaspase-3 during Oligodendrocyte Fate Decisions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  11. Evolution of Oligodendroglia and Myelin.Advances in neurobiology · 2025
    Review
  12. Glial Regulation of Circuit Wiring, Firing, and Expiring in theCold Spring Harbor perspectives in biology · 2024
    Review
  13. Glial Regulation of Circuit Wiring, Firing, and Expiring in theCold Spring Harbor perspectives in biology · 2024
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Regulators of Oligodendrocyte Differentiation.Cold Spring Harbor perspectives in biology · 2024
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Robert A HillDepartment of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA robert.hill@dartmouth.edu.ORCID 0000-0001-6080-8712
Akiko NishiyamaDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut 06269, USA.
Ethan G HughesDepartment of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.

Funding

Inflammation and NG2 Cell DifferentiationR01NS073425 · NINDS · UNIVERSITY OF CONNECTICUT STORRS · PI NISHIYAMA, AKIKO · 2011 to 2021
$3.3M
The role of myelination in cortical circuit function and motor behaviorR01NS115975 · NINDS · UNIVERSITY OF COLORADO DENVER · PI Ethan Garrett Hughes, Cristin G Welle · 2020 to 2026
$3.1M
Glial Mechanisms Governing the Removal and Repair of Degenerating MyelinR01NS122800 · NINDS · DARTMOUTH COLLEGE · PI HILL, ROBERT A. · 2021 to 2025
$2.3M
Precision of Myelin Plasticity in Health and DiseaseR01NS125230 · NINDS · UNIVERSITY OF COLORADO DENVER · PI Ethan Garrett Hughes · 2022 to 2026
$1.9M
SNARE complex-mediated exocytosis in oligodendrocyte differentiation and survivalR01NS116182 · NINDS · UNIVERSITY OF CONNECTICUT STORRS · PI NISHIYAMA, AKIKO · 2020 to 2024
$1.7M
NINDS NIH HHS R01 NS073425NINDS NIH HHS R01 NS115975NINDS NIH HHS R01 NS116182NINDS NIH HHS R01 NS122800NINDS NIH HHS R01 NS125230
6 · The paper itself

Abstract

Oligodendrocyte precursor cells (OPCs) are a central nervous system resident population of glia with a distinct molecular identity and an ever-increasing list of functions. OPCs generate oligodendrocytes throughout development and across the life span in most regions of the brain and spinal cord. This process involves a complex coordination of molecular checkpoints and biophysical cues from the environment that initiate the differentiation and integration of new oligodendrocytes that synthesize myelin sheaths on axons. Outside of their progenitor role, OPCs have been proposed to play other functions including the modulation of axonal and synaptic development and the participation in bidirectional signaling with neurons and other glia. Here, we review OPC identity and known functions and discuss recent findings implying other roles for these glial cells in brain physiology and pathology.

Indexed as

Oligodendrocyte Precursor CellsAxonsMyelin SheathNeuronsOligodendroglia

Identifiers

PMID38052500
PMCPMC10910408

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.