Evidence map›Paper›PMID 38052475›Full record

ArticleEpilepsia2024

Epilepsy phenotype and its reproducibility after lateral fluid percussion-induced traumatic brain injury in rats: Multicenter EpiBioS4Rx study project 1.

Xavier Ekolle Ndode-Ekane, Idrish Ali, Cesar Santana-Gomez, Pedro Andrade, Riikka Immonen, Pablo Casillas-Espinosa, Tomi Paananen, Eppu Manninen, Noora Puhakka, Gregory Smith and 13 more

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 3 institutions in 4 countries.

Xavier Ekolle Ndode-EkaneA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.ORCID https://orcid.org/0000-0001-5682-5632
Idrish AliDepartment of Neurology, Alfred Health, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0002-0971-4654
Cesar Santana-GomezDepartment of Neurology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA.ORCID https://orcid.org/0000-0001-9163-5615
Pedro AndradeA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Riikka ImmonenA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Pablo Casillas-EspinosaDepartment of Neurology, Alfred Health, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0002-6199-9415
Tomi PaananenA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Eppu ManninenA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.ORCID https://orcid.org/0000-0002-9353-6079
Noora PuhakkaA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Gregory SmithDepartment of Neurosurgery, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA.
Rhys D BradyDepartment of Neurology, Alfred Health, Melbourne, Victoria, Australia.
Juliana SilvaDepartment of Neurology, Alfred Health, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0002-2146-4221
Emma BraineDepartment of Neurology, Alfred Health, Melbourne, Victoria, Australia.
Matt HudsonDepartment of Neurology, Alfred Health, Melbourne, Victoria, Australia.
Glen R YamakawaDepartment of Neurology, Alfred Health, Melbourne, Victoria, Australia.
Nigel C JonesDepartment of Neurology, Alfred Health, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0002-1080-8439
Sandy R ShultzDepartment of Neurology, Alfred Health, Melbourne, Victoria, Australia.
Neil HarrisDepartment of Neurosurgery, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-1965-6750
David K WrightDepartment of Neurology, Alfred Health, Melbourne, Victoria, Australia.
Olli GröhnA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Richard StabaDepartment of Neurology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA.
Terence J O'BrienDepartment of Neurology, Alfred Health, Melbourne, Victoria, Australia.
Asla PitkänenA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.ORCID https://orcid.org/0000-0002-8163-5416
The Royal Melbourne Hospital · AUUniversity of Eastern Finland · FIUniversity of California, Los Angeles · US

Funding

The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) Public Engagement CoreU54NS100064 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ENGEL, JEROME NONE, GALANOPOULOU, ARISTEA S · 2017 to 2021
$21.7M
NIH HHS U54NS100064NINDS NIH HHS U54 NS100064
6 · The paper itself

Abstract

objectiveThis study was undertaken to assess reproducibility of the epilepsy outcome and phenotype in a lateral fluid percussion model of posttraumatic epilepsy (PTE) across three study sites.

methodsA total of 525 adult male Sprague Dawley rats were randomized to lateral fluid percussion-induced brain injury (FPI) or sham operation. Of these, 264 were assigned to magnetic resonance imaging (MRI cohort, 43 sham, 221 traumatic brain injury [TBI]) and 261 to electrophysiological follow-up (EEG cohort, 41 sham, 220 TBI). A major effort was made to harmonize the rats, materials, equipment, procedures, and monitoring systems. On the 7th post-TBI month, rats were video-EEG monitored for epilepsy diagnosis.

resultsA total of 245 rats were video-EEG phenotyped for epilepsy on the 7th postinjury month (121 in MRI cohort, 124 in EEG cohort). In the whole cohort (n = 245), the prevalence of PTE in rats with TBI was 22%, being 27% in the MRI and 18% in the EEG cohort (p > .05). Prevalence of PTE did not differ between the three study sites (p > .05). The average seizure frequency was .317 ± .725 seizures/day at University of Eastern Finland (UEF; Finland), .085 ± .067 at Monash University (Monash; Australia), and .299 ± .266 at University of California, Los Angeles (UCLA; USA; p < .01 as compared to Monash). The average seizure duration did not differ between UEF (104 ± 48 s), Monash (90 ± 33 s), and UCLA (105 ± 473 s; p > .05). Of the 219 seizures, 53% occurred as part of a seizure cluster (≥3 seizures/24 h; p >.05 between the study sites). Of the 209 seizures, 56% occurred during lights-on period and 44% during lights-off period (p > .05 between the study sites). SIGNIFICANCE: The PTE phenotype induced by lateral FPI is reproducible in a multicenter design. Our study supports the feasibility of performing preclinical multicenter trials in PTE to increase statistical power and experimental rigor to produce clinically translatable data to combat epileptogenesis after TBI.

Indexed as

Brain Injuries, TraumaticEpilepsyEpilepsy, Post-TraumaticAnimalsDisease Models, AnimalMalePercussionPhenotypeRatsRats, Sprague-DawleyReproducibility of ResultsSeizuresharmonizationposttraumatic epilepsypreclinicalvideo-EEG monitoring

Identifiers

PMID38052475
PMCPMC10922674
OpenAlexW4389358929

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.