Evidence map›Paper›PMID 38052373›Full record

ArticleBrain stimulation

High-throughput ultrasound neuromodulation in awake and freely behaving rats.

Tommaso Di Ianni, Kyle P Morrison, Brenda Yu, Keith R Murphy, Luis de Lecea, Raag D Airan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tommaso Di IanniDepartment of Radiology, Stanford University, Stanford, 94305, CA, USA; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, 94158, CA, USA; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, 94158, CA, USA. Electronic address: tommaso.diianni@ucsf.edu.
Kyle P MorrisonSonic Concepts, Inc., Bothell, 98011, WA, USA.
Brenda YuDepartment of Radiology, Stanford University, Stanford, 94305, CA, USA.
Keith R MurphyDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, 94305, CA, USA.
Luis de LeceaDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, 94305, CA, USA.
Raag D AiranDepartment of Radiology, Stanford University, Stanford, 94305, CA, USA; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, 94305, CA, USA; Department of Materials Science and Engineering, Stanford University, Stanford, 94305, CA, USA. Electronic address: rairan@stanford.edu.

Funding

Clinical Translation of Ultrasonic Ketamine Uncaging for Non-Opioid Therapy of Chronic PainUG3NS115637 · NINDS · STANFORD UNIVERSITY · PI Raag D Airan, Boris Dov Heifets · 2019 to 2026
$8.0M
Clinical Translation of Targeted and Noninvasive Ultrasonic Propofol UncagingUG3NS114438 · NINDS · STANFORD UNIVERSITY · PI AIRAN, RAAG D · 2021 to 2021
$3.8M
Noninvasive neuromodulation via focused ultrasonic drug uncagingRF1MH114252 · NIMH · STANFORD UNIVERSITY · PI AIRAN, RAAG D · 2017 to 2017
$1.6M
NIMH NIH HHS RF1 MH114252NINDS NIH HHS UG3 NS114438NINDS NIH HHS UG3 NS115637
6 · The paper itself

Abstract

Transcranial ultrasound neuromodulation is a promising potential therapeutic tool for the noninvasive treatment of neuropsychiatric disorders. However, the expansive parameter space and difficulties in controlling for peripheral auditory effects make it challenging to identify ultrasound sequences and brain targets that may provide therapeutic efficacy. Careful preclinical investigations in clinically relevant behavioral models are critically needed to identify suitable brain targets and acoustic parameters. However, there is a lack of ultrasound devices allowing for multi-target experimental investigations in awake and unrestrained rodents. We developed a miniaturized 64-element ultrasound array that enables neurointerventional investigations with within-trial active control targets in freely behaving rats. We first characterized the acoustic field with measurements in free water and with transcranial propagation. We then confirmed in vivo that the array can target multiple brain regions via electronic steering, and verified that wearing the device does not cause significant impairments to animal motility. Finally, we demonstrated the performance of our system in a high-throughput neuromodulation experiment, where we found that ultrasound stimulation of the rat central medial thalamus, but not an active control target, promotes arousal and increases locomotor activity.

Indexed as

BrainWakefulnessAnimalsArousalRatsUltrasonographyArousalCentral medial thalamusCMTFreely behaving ratsNeuromodulationTranscranial ultrasoundWearable array

Identifiers

PMID38052373
PMCPMC10795522

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.