Evidence map›Paper›PMID 38052228›Full record

ArticleNature2024

Hypoblast from human pluripotent stem cells regulates epiblast development.

Takumi Okubo, Nicolas Rivron, Mio Kabata, Hideki Masaki, Keiko Kishimoto, Katsunori Semi, May Nakajima-Koyama, Haruko Kunitomi, Belinda Kaswandy, Hideyuki Sato and 6 more

Erratum issuedAbstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Synthetic embryos: current progress, application and challenges.Reproductive biology and endocrinology : RB&E · 2026
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Mechanisms of human germ cell development.Nature reviews. Molecular cell biology · 2026
    Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Linking tissue morphology and tissue healing in a cell-fate model.Frontiers in cell and developmental biology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Takumi OkuboCenter for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.ORCID 0009-0009-6627-8383
Nicolas RivronInstitute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Vienna, Austria.ORCID 0000-0003-1590-5964
Mio KabataCenter for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.
Hideki MasakiInstitute of Medical Science, University of Tokyo, Tokyo, Japan.
Keiko KishimotoCentral Institute for Experimental Animals, Kawasaki, Japan.
Katsunori SemiCenter for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.
May Nakajima-KoyamaCenter for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.
Haruko KunitomiCenter for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.ORCID 0000-0003-3045-337X
Belinda KaswandyCenter for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.
Hideyuki SatoInstitute of Medical Science, University of Tokyo, Tokyo, Japan.
Hiromitsu NakauchiInstitute of Medical Science, University of Tokyo, Tokyo, Japan.ORCID 0000-0002-9841-6973
Knut WoltjenCenter for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.ORCID 0000-0003-2293-1183
Mitinori SaitouCenter for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.
Erika SasakiCentral Institute for Experimental Animals, Kawasaki, Japan.ORCID 0000-0002-0415-5400
Takuya YamamotoCenter for iPS Cell Research and Application, Kyoto University, Kyoto, Japan. takuya@cira.kyoto-u.ac.jp.ORCID 0000-0002-0022-3947
Yasuhiro TakashimaCenter for iPS Cell Research and Application, Kyoto University, Kyoto, Japan. y.takashima@cira.kyoto-u.ac.jp.ORCID 0000-0003-0126-7260

Funding

MEXT KAKENHI
6 · The paper itself

Abstract

Recently, several studies using cultures of human embryos together with single-cell RNA-seq analyses have revealed differences between humans and mice, necessitating the study of human embryos

Indexed as

Embryonic DevelopmentGerm LayersPluripotent Stem CellsAmnionCell DifferentiationEctodermEmbryo ImplantationEmbryo, MammalianGastrulaHumansIntercellular Signaling Peptides and ProteinsInterleukin-6Otx Transcription FactorsDKK1 protein, humanIL6 protein, humanIntercellular Signaling Peptides and ProteinsInterleukin-6OTX2 protein, humanOtx Transcription Factors

Identifiers

PMID38052228
PMCPMC10849967

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.