Evidence map›Paper›PMID 38052000›Full record

ArticleFuture virology2023

Yousef A Abdelrady, Naeem Mahmood Ashraf, Arslan Hamid, Hayam S Thabet, Asmaa M Sayed, Shimaa H Salem, Emad Hm Hassanein, Ahmed M Sayed

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Future virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yousef A AbdelradyFaculty of Pharmacy, Assiut University, Assiut, 71526, Egypt.ORCID https://orcid.org/0000-0003-0198-995X
Naeem Mahmood AshrafSchool of Biochemistry & Biotechnology, University of the Punjab, Lahore, Pakistan.
Arslan HamidLIMES Institute (AG-Netea), University of Bonn, Bonn, Germany.
Hayam S ThabetMicrobiology department, Faculty of Veterinary Medicine, Assiut University, 71526, Egypt.
Asmaa M SayedBotany & Microbiology Department, Faculty of Science, Assiut University, Egypt.
Shimaa H SalemBotany & Microbiology Department, Faculty of Science, Assiut University, Egypt.
Emad Hm HassaneinDepartment of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt.
Ahmed M SayedBiochemistry Laboratory, Chemistry Department, Faculty of Science, Assiut University, 71516, Egypt.ORCID https://orcid.org/0000-0002-3349-2545

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: We aimed to investigate the potential inhibitory effects of diterpenes on SARS-CoV-2 main protease (Mpro). Materials & methods: We performed a virtual screening of diterpenoids against Mpro using molecular docking, molecular dynamics simulation and absorption, distribution, metabolism and excretion) analysis. Results: Some tested compounds followed Lipinski's rule and showed drug-like properties. Some diterpenoids possessed remarkable binding affinities with SARS-CoV-2 Mpro and drug-like pharmacokinetic properties. Three derivatives exhibited structural deviations lower than 1 Å. Conclusion: The findings of the study suggest that some of the diterpenes could be candidates as potential inhibitors for Mpro of SARS-CoV-2.

Indexed as

diterpenesinhibitorsmolecular dockingMproSARS-CoV-2

Identifiers

PMID38052000
PMCPMC10207350

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.