Evidence map›Paper›PMID 38051371›Full record

ArticleArchives of gynecology and obstetrics2024

The effects of flexible short protocol with gonadotropin-releasing hormone antagonist on preventing premature ovulation in poor responders.

Yan Zhang, Hongyou Wang, Xinyue Zhang, Yingying Hao, Jihong Yang, Yangbai Li, Ting Feng, Yandong Chen, Yun Qian

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of gynecology and obstetrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yan Zhang *Reproductive Center, Second Affiliated Hospital, Nanjing Medical University, Nanjing, 210011, China.
Hongyou Wang *Department of Obstetrics and Gynecology, Binhai County People's Hospital, Yancheng, 224000, China.
Xinyue ZhangReproductive Center, Second Affiliated Hospital, Nanjing Medical University, Nanjing, 210011, China.
Yingying HaoReproductive Center, Second Affiliated Hospital, Nanjing Medical University, Nanjing, 210011, China.
Jihong YangReproductive Center, Second Affiliated Hospital, Nanjing Medical University, Nanjing, 210011, China.
Yangbai LiReproductive Center, Second Affiliated Hospital, Nanjing Medical University, Nanjing, 210011, China.
Ting FengReproductive Center, Second Affiliated Hospital, Nanjing Medical University, Nanjing, 210011, China.
Yandong ChenReproductive Center, Second Affiliated Hospital, Nanjing Medical University, Nanjing, 210011, China.
Yun QianReproductive Center, Second Affiliated Hospital, Nanjing Medical University, Nanjing, 210011, China. qianyun@njmu.edu.cn.ORCID 0000-0003-4669-9737
Second Affiliated Hospital of Nanjing Medical University · CNBinzhou People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe proportion of patients with poor ovarian response (POR) is increasing, but effective treatment remains a challenge. To control the hidden peaks of luteinizing hormone (LH) and premature ovulation for poor responders, this study investigated the efficacy of flexible short protocol (FSP) with gonadotropin-releasing hormone antagonist (GnRH-ant) on trigger day.

methodsThe 662 cycles of POR patients were retrospectively analyzed. The cohort was divided into control and intervention groups. The intervention group (group A) with 169 cycles received a GnRH-ant given on trigger day. The control (group B) with 493 cycles received only FSP. The clinical outcomes of the two groups were compared.

resultsCompared with group B, with gonadotropin-releasing hormone antagonist (GnRH-ant) on trigger day in group A the incidences of spontaneous premature ovulation decreased significantly (2.37% vs. 8.72%, P < 0.05). The number of fresh embryo-transfer cycles was 45 in group A and 117 in group B. There were no significant differences in clinical outcomes, including implantation rate, clinical pregnancy rate, live birth rate and the cumulative live birth rate (12.0% vs. 9.34%; 22.22% vs. 21.93%; 17.78% vs. 14.91%; 20.51% vs. 20%, respectively; P > 0.05) between the two group.

conclusionFSP with GnRH-ant addition on trigger day had no effect on clinical outcomes, but could effectively inhibit the hidden peaks of luteinizing hormone (LH) and spontaneous premature ovulation in POR. Therefore, it is an advantageous option for POR women.

Indexed as

Gonadotropin-Releasing HormonePremature BirthFemaleFertilization in VitroHormone AntagonistsHumansLuteinizing HormoneOvulationOvulation InductionPregnancyPregnancy RateRetrospective StudiesGonadotropin-Releasing HormoneHormone AntagonistsLuteinizing HormoneGnRH antagonistLive birthOvarian stimulationPoor ovarian responsePregnancy ratePremature ovulation

Identifiers

PMID38051371
PMCPMC10808440
OpenAlexW4389346461

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.