ArticleActa crystallographica. Section F, Structural biology communications2023
The crystal structure of the human smacovirus 1 Rep domain.
Lidia K Limón, Ke Shi, Amy Dao, Jacob Rugloski, Kassidy J Tompkins, Hideki Aihara, Wendy R Gordon, Robert L Evans
Open access · hybridAbstract read
In one paragraphArticle in Acta crystallographica. Section F, Structural biology communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors at 1 institution in 1 country.
Lidia K LimónDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Ke ShiDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Amy DaoDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0003-4374-2007 Jacob RugloskiDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0001-6976-6651 Kassidy J TompkinsDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Hideki AiharaDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0001-7508-6230 Wendy R GordonDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Robert L EvansDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
University of Minnesota · US
Funding
User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI STEVEN E EALICK · 2018 to 2026
$34.2MTRAINING PROGRAM IN MUSCLE RESEARCHT32AR007612 · NIAMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI JAMES M ERVASTI, DAWN A LOWE · 2001 to 2026
$11.3MStructural studies of viral replication and invasionR35GM118047 · NIGMS · UNIVERSITY OF MINNESOTA · PI Hideki Aihara · 2016 to 2026
$6.3MMechanism and modulation of Amyloid Precursor Protein proteolysisR35GM119483 · NIGMS · UNIVERSITY OF MINNESOTA · PI WENDY RYAN GORDON · 2016 to 2026
$4.6MNIAMS NIH HHS T32 AR007612NIGMS NIH HHS P30 GM124165NIGMS NIH HHS R35 GM118047NIGMS NIH HHS R35 GM119483NIH HHS R35 GM118047NIH HHS T32 AR007612
6 · The paper itselfAbstract
Replication initiator proteins (Reps) from the HUH endonuclease family process specific single-stranded DNA sequences to initiate rolling-circle replication in viruses. Here, the first crystal structure of the apo state of a Rep domain from the smacovirus family is reported. The structure of the human smacovirus 1 Rep domain was obtained at 1.33 Å resolution and represents an expansion of the HUH endonuclease superfamily, allowing greater diversity in bioconjugation-tag applications.
Indexed as
DNA, Single-StrandedEndonucleasesCrystallography, X-RayDNA, ViralHumansDNA, Single-StrandedDNA, ViralEndonucleasesbioconjugationcrystal structureHUH endonucleasesHUH-tagsRep domainssmacovirusesssDNA
Identifiers
PMID38051309
PMCPMC10833120
OpenAlexW4389363499
What OpenQuestion holds
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LicenceCC BY
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