Evidence map›Paper›PMID 38051116›Full record

ArticlemBio2024

The mating pilus of

Leticia Beltrán, Holly Torsilieri, Jonasz B Patkowski, Jie E Yang, James Casanova, Tiago R D Costa, Elizabeth R Wright, Edward H Egelman

Open access · goldAbstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. The extended mobility of plasmids.Nucleic acids research · 2025
    Review
  9. Cryo-EM structure of the conjugation H-pilus reveals the cyclic nature of the TrhA pilin.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
  11. Article
  12. ThemicroLife · 2025
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Leticia BeltránDepartment of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, USA.
Holly TorsilieriDepartment of Molecular Cell Biology, University of Virginia, Charlottesville, Virginia, USA.
Jonasz B PatkowskiDepartment of Life Sciences, Centre for Bacterial Resistance Biology, Imperial College London, London, United Kingdom.ORCID 0000-0001-7301-1569
Jie E YangDepartment of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
James CasanovaDepartment of Molecular Cell Biology, University of Virginia, Charlottesville, Virginia, USA.
Tiago R D CostaDepartment of Life Sciences, Centre for Bacterial Resistance Biology, Imperial College London, London, United Kingdom.
Elizabeth R WrightDepartment of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0003-0712-9475
Edward H EgelmanDepartment of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0003-4844-5212
University of Virginia · USImperial College London · GBUniversity of Wisconsin–Madison · US

Funding

Women's Oncology Program - WONP30CA044579 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Jay William FOX · 1987 to 2026
$72.1M
The Midwest Center for Cryo-Electron TomographyU24GM139168 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI WRIGHT, ELIZABETH R · 2020 to 2025
$41.7M
Cryo-EM of Helical Protein and Nucleoprotein Polymers at Near Atomic ResolutionR35GM122510 · NIGMS · UNIVERSITY OF VIRGINIA · PI EDWARD H. EGELMAN · 2017 to 2026
$7.3M
NCI NIH HHS P30 CA044579NIGMS NIH HHS R35 GM122510NIGMS NIH HHS U24 GM139168
6 · The paper itself

Abstract

importanceBacteria are constantly exchanging DNA, which constitutes horizontal gene transfer. While some of these occurs by a non-specific process called natural transformation, some occurs by a specific mating between a donor and a recipient cell. In specific conjugation, the mating pilus is extended from the donor cell to make contact with the recipient cell, but whether DNA is actually transferred through this pilus or by another mechanism involving the type IV secretion system complex without the pilus has been an open question. Using

Indexed as

Escherichia coliGene Transfer, HorizontalConjugation, GeneticDNA, BacterialFimbriae, BacterialPlasmidsDNA, Bacterialconjugation piluscryo-EMhorizontal gene transfer

Identifiers

PMID38051116
PMCPMC10790687
OpenAlexW4389336131

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.