Evidence map›Paper›PMID 38050689›Full record

ArticleJournal of neurophysiology2024

cAMP-dependent protein kinase signaling is required for (

Lace M Riggs, Edna F R Pereira, Scott M Thompson, Todd D Gould

Open access · greenAbstract read
In one paragraph

Article in Journal of neurophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. A Time-Sensitive Plasticity Distinguishes the Rapid and Sustained Synaptic Actions of Ketamine from Its (2The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  4. The hippocampus as a central hub in ketamine's antidepressant action: from molecules to circuit rewiring.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Rapid hippocampal synaptic potentiation induced by ketamine metabolite (2R,6R)-hydroxynorketamine persistently primes synaptic plasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Lace M RiggsProgram in Neuroscience and Training Program in Integrative Membrane Biology, University of Maryland School of Medicine, Baltimore, Maryland, United States.
Edna F R PereiraDepartment of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0003-0399-762X
Scott M ThompsonDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, United States.
Todd D GouldDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0003-1511-7183
University of Maryland, Baltimore · US

Funding

Therapeutic Efficacy of Ketamine Metabolites for Depression TreatmentR01MH107615 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI GOULD, TODD D · 2016 to 2025
$7.2M
TRAINING PROGRAM IN INTEGRATIVE MEMBRANE BIOLOGYT32GM008181 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI RIZZO, MEGAN A, TRUDEAU, MATTHEW C · 1987 to 2022
$4.9M
Stress, Depression, Serotonin, and Plasticity of Excitatory TransmissionR01MH086828 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI THOMPSON, SCOTT M. · 2010 to 2019
$3.8M
Synaptic mechanisms underlying the rapid antidepressant properties of the (2R,6R)-hydroxynorketamine metaboliteF31MH123066 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI RIGGS, LACE MARIE · 2020 to 2021
$55k
Targeting the inflammatory response to treat post-traumatic anxiety and depression.I01BX003631 · VA · BALTIMORE VA MEDICAL CENTER · PI GOULD, TODD D · 2017 to 2021
–
Hydroxynorketamine for the Treatment of PTSD and AnhedoniaI01BX004062 · VA · BALTIMORE VA MEDICAL CENTER · PI GOULD, TODD D · 2019 to 2023
–
BLRD VA I01 BX003631BLRD VA I01 BX004062NIGMS NIH HHS T32 GM008181NIMH NIH HHS F31 MH123066NIMH NIH HHS R01 MH086828NIMH NIH HHS R01 MH107615
6 · The paper itself

Abstract

(

Indexed as

KetamineAnimalsAntidepressive AgentsBrain-Derived Neurotrophic FactorGlutamic AcidHippocampusMaleRats6-hydroxynorketamineAntidepressive AgentsBrain-Derived Neurotrophic FactorGlutamic AcidKetamineBDNFhippocampusPKATrkBWistar Kyoto rat

Identifiers

PMID38050689
PMCPMC11286304
OpenAlexW4389346328

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.