Evidence map›Paper›PMID 38050487›Full record

ArticlePediatric diabetes2023

Increased Use of Hyperosmolar Therapy for Suspected Clinically Apparent Brain Injury in Pediatric Patients with Diabetic Ketoacidosis during the Peak of the COVID-19 Pandemic.

Svetlana Azova, Enju Liu, Joseph Wolfsdorf

Abstract read
In one paragraph

Article in Pediatric diabetes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Svetlana AzovaDivision of Endocrinology, Boston Children's Hospital, Boston, Massachusetts 02115, USA.ORCID 0000-0003-3685-1387
Enju LiuInstitutional Centers for Clinical and Translational Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.ORCID 0000-0002-5732-3359
Joseph WolfsdorfDivision of Endocrinology, Boston Children's Hospital, Boston, Massachusetts 02115, USA.ORCID 0000-0001-6220-6758

Funding

Research in Development Endocrinology and MetabolismT32DK007699 · NIDDK · CHILDREN'S HOSPITAL BOSTON · PI JOEL N HIRSCHHORN · 1992 to 2026
$7.1M
NIDDK NIH HHS T32 DK007699
6 · The paper itself

Abstract

The incidence of pediatric diabetic ketoacidosis (DKA) increased during the peak of the COVID-19 pandemic. The objective of this study was to investigate whether rates of hyperosmolar therapy administration for suspected clinically apparent brain injury (CABI) complicating DKA also increased during this period as compared to the three years immediately preceding the pandemic and to compare the characteristics of patients with suspected CABI before the pandemic, patients with suspected CABI during the peak of the pandemic, and those with DKA but without suspected CABI during the pandemic. Patients aged ≤18 years presenting with DKA before (March 11, 2017-March 10, 2020) and during the peak of the pandemic (March 11, 2020-March 10, 2021) were identified through a rigorous search of two databases. Predefined criteria were used to diagnose suspected CABI. Biochemical, clinical, and sociodemographic data were collected from a comprehensive review of the electronic medical record. The proportion of patients with DKA who received hyperosmolar therapy was significantly higher (

Indexed as

COVID-19Diabetes Mellitus, Type 1Diabetic KetoacidosisHyperglycemic Hyperosmolar Nonketotic ComaChildHospitalizationHumansPandemics

Identifiers

PMID38050487
PMCPMC10695073

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.