ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2024
Contrast Sensitivity of ON and OFF Human Retinal Pathways in Myopia.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 37 citations in OpenAlex.
- Sustained Plus Lens Defocus Alters Retinal Responses and Ciliary Muscle Morphology In Myopes and Near-emmetropes.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Mesopic Illumination in Natural Environments: Implications for Myopia Research.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Reduced myopia progression with low-dose atropine in DIMS non-responders and evidence of altered pupillary light reflex kinetics.Scientific reports · 2026Article
- Model of naturally occurring refractive error (NORE) in mice.bioRxiv : the preprint server for biology · 2026Article
- Subclinical Structural and Functional Retinal Alterations in Clinically Normal Myopic Eyes.Journal of clinical medicine · 2026Article
- Optically Induced Peripheral Contrast Reduction Restores ON/OFF Pathway Balance in Myopic Eyes.Ophthalmology science · 2026Article
- Human accommodative visuomotor function is driven by contrast through ON and OFF pathways and is enhanced in myopia.Cell reports · 2026Article
- IMI: The Role of Light in Refractive Development and Myopia: Evidence from Animal and Human Studies.Investigative ophthalmology & visual science · 2025Review
- Exploration of visual perception metrics as indicators for myopia screening.Lasers in medical science · 2025Article
- Visual Distortions in Human Amblyopia Are Correlated with Deficits in Contrast Sensitivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Methylphenidate Inhibits the Development of Myopia by Altering Dopamine and Norepinephrine Reuptake.Investigative ophthalmology & visual science · 2025Article
- Orthokeratology for myopia control: a three-year longitudinal study on axial length modulation influenced by baseline age and spherical equivalent.BMC ophthalmology · 2025Article
- Asymmetric activation of retinal ON and OFF pathways by AOSLO raster-scanned visual stimuli.Biomedical optics express · 2025Article
- Comparison of visual functions among early and late onset myopia.Scientific reports · 2025Article
- Relative Role of ON/OFF Pathways in Resolving and Adapting to Blur in Myopes and Emmetropes.Investigative ophthalmology & visual science · 2025Article
- Article
- Optical and Visual Diet in Myopia.Investigative ophthalmology & visual science · 2025Review
- Effect of repeated Low-Level red light therapy on axial length in myopic individuals: predictors for a good response.BMC ophthalmology · 2025Article
- Efficacy of naked-eye 3D technology in mitigating myopia progression among children.Translational pediatrics · 2025Article
- Associations between RetNet gene polymorphisms and the efficacy of orthokeratology for myopia control: a retrospective clinical study.Eye and vision (London, England) · 2025Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The human visual cortex processes light and dark stimuli with ON and OFF pathways that are differently modulated by luminance contrast. We have previously demonstrated that ON cortical pathways have higher contrast sensitivity than OFF cortical pathways and the difference increases with luminance range (defined as the maximum minus minimum luminance in the scene). Here, we demonstrate that these ON-OFF cortical differences are already present in the human retina and that retinal responses measured with electroretinography are more affected by reductions in luminance range than cortical responses measured with electroencephalography. Moreover, we show that ON-OFF pathway differences measured with electroretinography become more pronounced in myopia, a visual disorder that elongates the eye and blurs vision at far distance. We find that, as the eye axial length increases across subjects, ON retinal pathways become less responsive, slower in response latency, less sensitive, and less effective and slower at driving pupil constriction. Based on these results, we conclude that myopia is associated with a deficit in ON pathway function that decreases the ability of the retina to process low contrast and regulate retinal illuminance in bright environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.