ArticleBMC medicine2023
Proteomic insights into the associations between obesity, lifestyle factors, and coronary artery disease.
Article in BMC medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Pooled it
- Alcohol consumption and its association with cancer, cardiovascular, liver and brain diseases: a systematic review of Mendelian randomization studies.Frontiers in epidemiology · 2024Pooled it
- Article
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- Surgical Repair of Multiple Coronary Artery Aneurysms With Multivessel Coronary Disease.JACC. Case reports · 2026Article
- Blood pressure, plasma proteins, and cardiovascular diseases: a network Mendelian randomization and observational study.European heart journal · 2026Observational
- Integrative analysis of programmed cell death pathways reveals prognostic biomarkers and immune infiltration signatures in coronary artery disease.Journal of thoracic disease · 2025Article
- X-Chromosome-Linked miRNAs Regulate Sex Differences in Cardiac Physiology.Circulation research · 2025Article
- Unveiling CTRB2, RSPO3, KLOTB, and ROR1 as obesity-pancreatic disease association proteins: a comprehensive Mendelian randomization study.Gastroenterology report · 2025Article
- Systematic proteome-wide Mendelian randomization to prioritize causal plasma proteins for skin cancers.Communications biology · 2024Article
- Insights from immunomics and metabolomics on the associations between prostatic diseases and coronavirus disease 2019.Prostate international · 2024Article
- Integration of proteomics with prospective birth cohort to elucidate early life origins of cardiometabolic diseases: rationale, study design, lab assay, and quality control.Precision nutrition · 2024Article
- Proteomic analysis of cardiorespiratory fitness for prediction of mortality and multisystem disease risks.Nature medicine · 2024Article
- Comprehensive mendelian randomization analysis of plasma proteomics to identify new therapeutic targets for the treatment of coronary heart disease and myocardial infarction.Journal of translational medicine · 2024Article
- Mendelian randomization implicates circulating plasma proteins in gout risk and identifies candidate therapeutic targets.International journal of immunopathology and pharmacologyArticle
Corrections and comments
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Authors and funding
8 authors at 7 institutions in 4 countries.
Funding
Abstract
backgroundWe aimed to investigate the protein pathways linking obesity and lifestyle factors to coronary artery disease (CAD).
methodsSummary-level genome-wide association statistics of CAD were obtained from the CARDIoGRAMplusC4D consortium (60,801 cases and 123,504 controls) and the FinnGen study (R8, 39,036 cases and 303,463 controls). Proteome-wide Mendelian randomization (MR) analysis was conducted to identify CAD-associated blood proteins, supplemented by colocalization analysis to minimize potential bias caused by linkage disequilibrium. Two-sample MR analyses were performed to assess the associations of genetically predicted four obesity measures and 13 lifestyle factors with CAD risk and CAD-associated proteins' levels. A two-step network MR analysis was conducted to explore the mediating effects of proteins in the associations between these modifiable factors and CAD.
resultsGenetically predicted levels of 41 circulating proteins were associated with CAD, and 17 of them were supported by medium to high colocalization evidence. PTK7 (protein tyrosine kinase-7), RGMB (repulsive guidance molecule BMP co-receptor B), TAGLN2 (transgelin-2), TIMP3 (tissue inhibitor of metalloproteinases 3), and VIM (vimentin) were identified as promising therapeutic targets. Several proteins were found to mediate the associations between some modifiable factors and CAD, with PCSK9, C1S, AGER (advanced glycosylation end product-specific receptor), and MST1 (mammalian Ste20-like kinase 1) exhibiting highest frequency among the mediating networks.
conclusionsThis study suggests pathways explaining the associations of obesity and lifestyle factors with CAD from alterations in blood protein levels. These insights may be used to prioritize therapeutic intervention for further study.
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