Evidence map›Paper›PMID 38049581›Full record

ArticleNature immunology2024

The transcription factor Aiolos restrains the activation of intestinal intraepithelial lymphocytes.

Kentaro Yomogida, Tihana Trsan, Raki Sudan, Patrick F Rodrigues, Alina Ulezko Antonova, Harshad Ingle, Blanda Di Luccia, Patrick L Collins, Marina Cella, Susan Gilfillan and 3 more

Open access · greenAbstract read
In one paragraph

Article in Nature immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Kentaro YomogidaDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Denver, CO, USA.ORCID 0000-0003-4171-6606
Tihana TrsanDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-7549-2885
Raki SudanDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-9101-818X
Patrick F RodriguesDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-0214-0627
Alina Ulezko AntonovaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Harshad IngleDepartment of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-5439-8013
Blanda Di LucciaDepartment of Microbiology and Immunology, Stanford University, Stanford, CA, USA.
Patrick L CollinsDepartment of Microbial Infection and Immunity, Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, OH, USA.ORCID 0000-0003-4550-4272
Marina CellaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-1230-1313
Susan GilfillanDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-1672-0996
Megan T BaldridgeDepartment of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-7030-6131
Eugene M OltzDepartment of Microbial Infection and Immunity, Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, OH, USA.
Marco ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. mcolonna@wustl.edu.ORCID 0000-0001-5222-4987
Washington University in St. Louis · USThe Ohio State University · USStanford University · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Technology Development Project - Increasing the complexity of ex vivo human airway models for studying immune response to viral infectionU19AI142733 · NIAID · JACKSON LABORATORY · PI Anna Karolina Palucka · 2019 to 2026
$23.1M
Mucosal Immune Defense Mechanisms of the Urinary BladderU01AI095542 · NIAID · WASHINGTON UNIVERSITY · PI COLONNA, MARCO, HULTGREN, SCOTT J. · 2011 to 2020
$9.8M
CIS-REGULATORY CIRCUITS FOR ILC FUNCTION AND PLASTICITYR01AI134035 · NIAID · WASHINGTON UNIVERSITY · PI MARCO COLONNA, Eugene M Oltz · 2018 to 2026
$4.8M
The role of TGFbeta in development and function of salivary gland innate lymphoid cellsR01DE025884 · NIDCR · WASHINGTON UNIVERSITY · PI COLONNA, MARCO, WEISMAN, GARY ANDREW · 2017 to 2021
$3.5M
Plasticity of Innate Lymphoid Cells: Mechanisms and Biological ImpactR01DK124699 · NIDDK · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2020 to 2023
$1.4M
Impact of Aiolos on intestinal intraepithelial lymphocytesK08DK128544 · NIDDK · WASHINGTON UNIVERSITY · PI Kentaro Yomogida · 2022 to 2026
$807k
Gene regulatory architecture of CD56 bright natural killer cellsR21AI156411 · NIAID · OHIO STATE UNIVERSITY · PI COLLINS, PATRICK LEONARD · 2021 to 2022
$433k
NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NIAID NIH HHS R01 AI134035NIAID NIH HHS R21 AI156411NIAID NIH HHS U01 AI095542NIAID NIH HHS U19 AI142733NIDCR NIH HHS R01 DE025884NIDDK NIH HHS K08 DK128544NIDDK NIH HHS R01 DK124699
6 · The paper itself

Abstract

Intestinal intraepithelial lymphocytes (IELs) exhibit prompt innate-like responses to microenvironmental cues and require strict control of effector functions. Here we showed that Aiolos, an Ikaros zinc-finger family member encoded by Ikzf3, acted as a regulator of IEL activation. Ikzf3

Indexed as

Intraepithelial LymphocytesTranscription FactorsAnimalsCD8 AntigensIkaros Transcription FactorInterleukin-15Intestinal MucosaMiceMice, Inbred C57BLMice, KnockoutCD8 AntigensIkaros Transcription FactorIkzf3 protein, mouseInterleukin-15Transcription Factors

Identifiers

PMID38049581
PMCPMC11835375
OpenAlexW4389298349

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.