ArticleNature communications2023
Nitric oxide controls shoot meristem activity via regulation of DNA methylation.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- A GRX-SOD module maintains superoxide homeostasis and meristem development in maize.Advanced biotechnology · 2026Article
- Hydrogen-bond-mediated retention of a phenolic SNAP analogue in polyvinyl alcohol/PEG hydrogels for sustained nitric oxide release and antibacterial activity.Smart molecules : open access · 2026Article
- Newly found functions and regulatory networks of WOX family: what else does the WOX say?Planta · 2026Review
- WUSCHEL Transcription Factor: From Stem Cell Maintenance to Crop Improvement.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Aging drives a program of DNA methylation decay in plant organs.Science (New York, N.Y.) · 2026Article
- Stem cell regulation: conserved pluripotency, transcriptional, and metabolic networks in animals and plants.Frontiers in cell and developmental biology · 2026Review
- DNA methylation dynamics: patterns, regulation, and function.Current opinion in plant biology · 2025Review
- The Hidden Architects: Nitric Oxide and Redox Dynamics in Plant Stem Cell Homeostasis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Plants repress ROS1 expression to attenuate heat-induced transposon burst.Nature plants · 2025Article
- Plant epigenetics: controlling genome expression to integrate developmental and environmental cues.Journal of experimental botany · 2025Article
- ERFVIIs as transducers of oxygen-sensing in the evolution of land plant response to hypoxia.Molecular plant · 2025Article
- Article
- Microorganism microneedle micro-engine depth drug delivery.Nature communications · 2024Article
- Redox Reactivity of Nonsymbiotic Phytoglobins towards Nitrite.Molecules (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 2 countries.
Funding
Abstract
Despite the importance of Nitric Oxide (NO) as signaling molecule in both plant and animal development, the regulatory mechanisms downstream of NO remain largely unclear. Here, we show that NO is involved in Arabidopsis shoot stem cell control via modifying expression and activity of ARGONAUTE 4 (AGO4), a core component of the RNA-directed DNA Methylation (RdDM) pathway. Mutations in components of the RdDM pathway cause meristematic defects, and reduce responses of the stem cell system to NO signaling. Importantly, we find that the stem cell inducing WUSCHEL transcription factor directly interacts with AGO4 in a NO dependent manner, explaining how these two signaling systems may converge to modify DNA methylation patterns. Taken together, our results reveal that NO signaling plays an important role in controlling plant stem cell homeostasis via the regulation of de novo DNA methylation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.