Evidence map›Paper›PMID 38049401›Full record

ArticleNature communications2023

Autoencoder neural networks enable low dimensional structure analyses of microbial growth dynamics.

Yasa Baig, Helena R Ma, Helen Xu, Lingchong You

Abstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. A foundation model for microbial growth dynamics.bioRxiv : the preprint server for biology · 2025
    Article
  8. Review
  9. Review
  10. Article
  11. Dynamics of an algae-bacteria microcosm: Photosynthesis, chemotaxis, and expulsion in inhomogeneous active matter.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yasa BaigDepartment of Physics, Duke University, Durham, NC, USA.
Helena R MaDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.ORCID 0000-0003-3659-7948
Helen XuDepartment of Computer Science, Duke University, Durham, NC, USA.ORCID 0009-0001-5766-9130
Lingchong YouDepartment of Biomedical Engineering, Duke University, Durham, NC, USA. you@duke.edu.ORCID 0000-0003-3725-4007

Funding

Post-antibiotic effect and design of optimal antibiotic dosing protocolsR01GM098642 · NIGMS · DUKE UNIVERSITY · PI YOU, LINGCHONG · 2011 to 2025
$3.6M
Tradeoffs between fitness costs and transfer rates in horizontal gene transferR01AI125604 · NIAID · DUKE UNIVERSITY · PI LINGCHONG YOU · 2017 to 2026
$3.3M
Targeted control of self-transmissible plasmids by using engineered interfering plasmidsR01EB031869 · NIBIB · DUKE UNIVERSITY · PI YOU, LINGCHONG · 2021 to 2024
$1.5M
NIAID NIH HHS R01 AI125604NIBIB NIH HHS R01 EB031869NIGMS NIH HHS R01 GM098642
6 · The paper itself

Abstract

The ability to effectively represent microbiome dynamics is a crucial challenge in their quantitative analysis and engineering. By using autoencoder neural networks, we show that microbial growth dynamics can be compressed into low-dimensional representations and reconstructed with high fidelity. These low-dimensional embeddings are just as effective, if not better, than raw data for tasks such as identifying bacterial strains, predicting traits like antibiotic resistance, and predicting community dynamics. Additionally, we demonstrate that essential dynamical information of these systems can be captured using far fewer variables than traditional mechanistic models. Our work suggests that machine learning can enable the creation of concise representations of high-dimensional microbiome dynamics to facilitate data analysis and gain new biological insights.

Indexed as

MicrobiotaNeural Networks, ComputerBacteriaMachine Learning

Identifiers

PMID38049401
PMCPMC10696002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.