Evidence map›Paper›PMID 38049144›Full record

ArticleACS synthetic biology2023

Thomas A Hamilton, Benjamin R Joris, Arina Shrestha, Tyler S Browne, Sébastien Rodrigue, Bogumil J Karas, Gregory B Gloor, David R Edgell

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS synthetic biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Thomas A HamiltonDepartment of Biochemistry, Schulich School of Medicine & Dentistry, Western University, London N6A 5C1, ON, Canada.
Benjamin R JorisDepartment of Biochemistry, Schulich School of Medicine & Dentistry, Western University, London N6A 5C1, ON, Canada.
Arina ShresthaDepartment of Biochemistry, Schulich School of Medicine & Dentistry, Western University, London N6A 5C1, ON, Canada.
Tyler S BrowneDepartment of Biochemistry, Schulich School of Medicine & Dentistry, Western University, London N6A 5C1, ON, Canada.
Sébastien RodrigueDépartment de Biologie, Université de Sherbrooke, Sherbrooke J1K 2R1, QC, Canada.ORCID 0000-0002-5366-7234
Bogumil J KarasDepartment of Biochemistry, Schulich School of Medicine & Dentistry, Western University, London N6A 5C1, ON, Canada.ORCID 0000-0002-1199-4245
Gregory B GloorDepartment of Biochemistry, Schulich School of Medicine & Dentistry, Western University, London N6A 5C1, ON, Canada.
David R EdgellDepartment of Biochemistry, Schulich School of Medicine & Dentistry, Western University, London N6A 5C1, ON, Canada.ORCID 0000-0003-3858-6150
Western University · CAUniversité de Sherbrooke · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metagenomic sequences represent an untapped source of genetic novelty, particularly for conjugative systems that could be used for plasmid-based delivery of Cas9-derived antimicrobial agents. However, unlocking the functional potential of conjugative systems purely from metagenomic sequences requires the identification of suitable candidate systems as starting scaffolds for

Indexed as

Anti-Infective AgentsEscherichia coliConjugation, GeneticCRISPR-Cas SystemsHumansPlasmidsRNA, Guide, CRISPR-Cas SystemsAnti-Infective AgentsRNA, Guide, CRISPR-Cas Systemsantimicrobialbacterial conjugationCRISPR/Cas9DNA assemblyhuman metagenome

Identifiers

PMID38049144
PMCPMC10729033
OpenAlexW4389323386

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.