Evidence map›Paper›PMID 38048437›Full record

ArticleJournal of medicinal chemistry2023

Small Molecule Ligands of the BET-like Bromodomain,

Matthias Schiedel, Darius J B McArdle, Gilda Padalino, Anthony K N Chan, Josephine Forde-Thomas, Michael McDonough, Helen Whiteland, Manfred Beckmann, Rosa Cookson, Karl F Hoffmann and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Identification of novel bromodomain inhibitors ofAntimicrobial agents and chemotherapy · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Matthias SchiedelDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.ORCID 0000-0001-7365-3617
Darius J B McArdleDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.
Gilda PadalinoThe Department of Life Sciences (DLS), Aberystwyth University, Wales SY23 3DA, U.K.
Anthony K N ChanDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.ORCID 0000-0002-7091-1294
Josephine Forde-ThomasThe Department of Life Sciences (DLS), Aberystwyth University, Wales SY23 3DA, U.K.
Michael McDonoughDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.
Helen WhitelandThe Department of Life Sciences (DLS), Aberystwyth University, Wales SY23 3DA, U.K.
Manfred BeckmannThe Department of Life Sciences (DLS), Aberystwyth University, Wales SY23 3DA, U.K.
Rosa CooksonGlaxoSmithKline R&D, Stevenage, Hertfordshire SG1 2NY, U.K.
Karl F HoffmannThe Department of Life Sciences (DLS), Aberystwyth University, Wales SY23 3DA, U.K.ORCID 0000-0002-3932-5502
Stuart J ConwayDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.ORCID 0000-0002-5148-117X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Schistosomiasis is a disease affecting >200 million people worldwide, but its treatment relies on a single agent, praziquantel. To investigate new avenues for schistosomiasis control, we have conducted the first systematic analysis of bromodomain-containing proteins (BCPs) in a causative species,

Indexed as

SchistosomiasisSchistosomiasis mansoniAminoquinolinesAnimalsBenzoatesFemaleHumansLigandsOvipositionSchistosoma mansoni4-(1-acetyl-4-((4-chlorophenyl)amino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoic acidAminoquinolinesBenzoatesLigands

Identifiers

PMID38048437
PMCPMC10726355

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.