Evidence map›Paper›PMID 38048260›Full record

ArticleDermatology practical & conceptual2024

Burden of Disease in the Real-Life Setting of Patients with Atopic Dermatitis: Italian Data From the MEASURE-AD Study.

Giuseppe Argenziano, Santo Raffaele Mercuri, Paola Savoia, Paolo Amerio, Anna Belloni Fortina, Maria Rita Bongiorno, Maria Beatrice De Felici Del Giudice, Aurora Parodi, Nicola Pimpinelli, Luca Stingeni and 7 more

Open access · diamondAbstract read
In one paragraph

Article in Dermatology practical & conceptual, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 16 institutions in 4 countries.

Giuseppe ArgenzianoDermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.
Santo Raffaele MercuriUnit of Dermatology, IRCCS San Raffaele Hospital, Milan, Italy.
Paola SavoiaDepartment of Health Sciences, Università del Piemonte Orientale, Novara, Italy.
Paolo AmerioDermatologic Clinic, Department of Medicine and Aging Science and Dermatologic Clinic, University "G. d'Annunzio", Chieti-Pescara, Chieti, Italy.
Anna Belloni FortinaUnit of Pediatric Dermatology, Department of Medicine DIMED, University of Padua, Padua, Italy.
Maria Rita BongiornoSection of Dermatology, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.
Maria Beatrice De Felici Del GiudiceDermatologic Unit, University Hospital of Parma, Department of Medicine and Surgery, Parma, Italy.
Aurora ParodiDivision of Dermatology, Department of Health Sciences (DISSAL), University of Genoa, Genoa Italy and Ospedale Policlinico San Martino IRCCS, Genoa, Italy.
Nicola PimpinelliDermatology Unit, Department Health Sciences, University of Florence, Florence, Italy.
Luca StingeniDermatology Section, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Michela OrtoncelliMedical Sciences Department, Dermatologic Clinic, University of Turin, Turin, Italy.
Giuseppe StincoInstitute of Dermatology, University of Udine, Udine, Italy.
Giuliana GualbertiAbbVie SrL, Campoverde di Latina, Italy.
Anna LeviAbbVie SrL, Campoverde di Latina, Italy.
Valeria ScuderiAbbVie SrL, Campoverde di Latina, Italy.
Luca BianchiDermatology Unit, Tor Vergata University Hospital, Rome, Italy.
Giovanna MalaraUOC of Dermatology, Grande Ospedale Metropolitano "Bianchi Melacrino Morelli", Reggio Calabria, Italy.
ABB (Italy) · ITAbbVie (United States) · USAzienda ospedaliera "Bianchi-Melacrino-Morelli" · ITDepartment of Medical Sciences · BYIstituti di Ricovero e Cura a Carattere Scientifico · ITOspedale Policlinico San Martino · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Chieti-Pescara · ITUniversity of Florence · ITUniversity of Padua · ITUniversity of Palermo · ITUniversity of Parma · ITUniversity of Perugia · ITUniversity of Rome Tor Vergata · ITUniversity of Turin · ITUniversity of Udine · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAtopic dermatitis (AD) is a chronic inflammatory skin disease that negatively impacts the quality of life and work productivity of patients.

objectivesWe sought to evaluate the real-world burden of AD patients in Italy.

methodsThis sub-analysis of the MEASURE-AD multicountry study conducted between December 2019-2020 included patients diagnosed with moderate-to-severe AD eligible for or receiving systemic therapy in the previous 6 months. During a single visit, physician and patient-reported questionnaires were used.

resultsA total of 118 adult patients were enrolled and 57.6% (N = 68) of patients had moderate-to-severe AD at the time of enrolment according to the Eczema Area and Severity Index. Sleep disorders interfered with daily function in the previous week in 58.5% (N = 69) of patients, pruritus was severe in 50% (N = 59) and 42.4% (N = 50) reported a flare lasting >7 days in the previous 6 months. According to the Dermatology Quality of Life Index, 37.3% (N = 44) of patients reported a severe impact of AD and approximately 10% had clinical depression/anxiety. Current drug therapy was considered inadequate in controlling AD in 26.3% (N=31) of patients. Work activity impairment was 38.6±31.7% and monthly AD-related expenses were 148.6±134.6 Euros per patient.

conclusionsThis real-life study documents a high burden of disease in patients with moderate-severe AD in Italy.

Identifiers

PMID38048260
PMCPMC10868859
OpenAlexW4389346187

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.