Evidence map›Paper›PMID 38048255›Full record

ArticleChaos (Woodbury, N.Y.)2023

Locating saddle points using gradient extremals on manifolds adaptively revealed as point clouds.

A Georgiou, H Vandecasteele, J M Bello-Rivas, I Kevrekidis

Abstract read
In one paragraph

Article in Chaos (Woodbury, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Theory and Examples of Catch Bonds.The journal of physical chemistry. B · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

A GeorgiouDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA.ORCID 0000-0001-9717-0599
H VandecasteeleDepartment of Computer Science, KU Leuven, 3001 Leuven, Belgium.ORCID 0000-0001-6756-7050
J M Bello-RivasDepartment of Applied Mathematics and Statistics, Johns Hopkins University, Baltimore, Maryland 21218, USA.ORCID 0000-0002-2640-0737
I KevrekidisDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA.ORCID 0000-0003-2220-3522

Funding

T32: Predoctoral and Postdoctoral Training Program in Nanotechnology for Cancer ResearchT32CA153952 · NCI · JOHNS HOPKINS UNIVERSITY · PI Denis Wirtz · 2015 to 2026
$3.5M
NCI NIH HHS T32 CA153952
6 · The paper itself

Abstract

Steady states are invaluable in the study of dynamical systems. High-dimensional dynamical systems, due to separation of time scales, often evolve toward a lower dimensional manifold M. We introduce an approach to locate saddle points (and other fixed points) that utilizes gradient extremals on such a priori unknown (Riemannian) manifolds, defined by adaptively sampled point clouds, with local coordinates discovered on-the-fly through manifold learning. The technique, which efficiently biases the dynamical system along a curve (as opposed to exhaustively exploring the state space), requires knowledge of a single minimum and the ability to sample around an arbitrary point. We demonstrate the effectiveness of the technique on the Müller-Brown potential mapped onto an unknown surface (namely, a sphere). Previous work employed a similar algorithmic framework to find saddle points using Newton trajectories and gentlest ascent dynamics; we, therefore, also offer a brief comparison with these methods.

Identifiers

PMID38048255
PMCPMC10697725

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.