Evidence map›Paper›PMID 38048186›Full record

ArticleAging2023

Down-regulation of EZH2 genes targeting RUNX3 affects proliferation, invasion, and metastasis of human colon cancer cells by Wnt/β-catenin signaling pathway.

Guanli Liang, Lei Han, Ming Qu, Jun Xue, Dandan Xu, Xueliang Wu, Yonggang Lu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Guanli LiangDepartment of General Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, China.
Lei HanDepartment of General Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, China.
Ming QuDepartment of General Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, China.
Jun XueDepartment of General Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, China.
Dandan XuCentral Laboratory, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, China.
Xueliang WuDepartment of General Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, China.
Yonggang LuClinical Laboratory, Hebei General Hospital, Shijiazhuang, Shijiazhuang 05000, China.
Hebei North University · CNHebei General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In order to detect the effect of EZH2 genes on proliferation, migration, invasion, and apoptosis of colon carcinoma cell strains HCT116 and HT29 by the Wnt/β-catenin signaling pathway, qRT-PCR was applied to measure relative expressions of EZH2, RUNX3, CEA, CA199, MMP-9, VEGF, β-catenin, and CyclinD1 in each group; Western-blot was employed with the intention of exploring relative expressions of these proteins

Indexed as

CarcinomaColonic NeoplasmsMicroRNAsAnimalsbeta CateninCell Line, TumorCell MovementCell ProliferationCore Binding Factor Alpha 3 SubunitDown-RegulationEnhancer of Zeste Homolog 2 ProteinGene Expression Regulation, NeoplasticHumansMatrix Metalloproteinase 9MiceMice, Nudebeta CateninCore Binding Factor Alpha 3 SubunitEnhancer of Zeste Homolog 2 ProteinEZH2 protein, humanMatrix Metalloproteinase 9MicroRNAsRunx3 protein, humanVascular Endothelial Growth Factor AEZH2HCT116HT29RUNX3Wnt/β-catenin signaling pathway

Identifiers

PMID38048186
PMCPMC10756104
OpenAlexW4389274759

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.