Evidence map›Paper›PMID 38047704›Full record

ArticleMicrobiology spectrum2024

Marco J van Belkum, Tamara Aleksandrzak-Piekarczyk, Tess Lamer, John C Vederas

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Design of Novel Saposin-like Bacteriocins Using a Hybrid Approach.Probiotics and antimicrobial proteins · 2025
    Article
  3. Solution Structure of the Broad-Spectrum Bacteriocin Garvicin Q.International journal of molecular sciences · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Marco J van BelkumDepartment of Chemistry, University of Alberta , Edmonton, Alberta, Canada.ORCID 0000-0002-9296-6069
Tamara Aleksandrzak-PiekarczykInstitute of Biochemistry and Biophysics, Polish Academy of Sciences (IBB PAS) , Warsaw, Poland.ORCID 0000-0002-4725-760X
Tess LamerDepartment of Chemistry, University of Alberta , Edmonton, Alberta, Canada.
John C VederasDepartment of Chemistry, University of Alberta , Edmonton, Alberta, Canada.
University of Alberta · CAInstitute of Biochemistry and Biophysics, Polish Academy of Sciences · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

importanceMany bacteriocins target the sugar transporter mannose phosphotransferase system (man-PTS) to exert their antibacterial activity. The elucidation in recent years of the structure of man-PTS has facilitated our understanding of how bacteriocins might interact with the receptor and which domains of the transporter are involved in bacteriocin resistance. Here, we show that missense mutations in the sugar-binding domain of the man-PTS not only impede the uptake of sugars but also prevent the antibacterial activity of the bacteriocins lactococcin A and garvicin Q.

Indexed as

BacteriocinsLactococcus lactisAnti-Bacterial AgentsHumansMannoseMutation, MissensePhosphotransferasesAnti-Bacterial AgentsBacteriocinslactococcin AMannosePhosphotransferasesbacteriocinsfusion proteingarvicin Qlactococcin Aman-PTSmutational studiesresistancesugar

Identifiers

PMID38047704
PMCPMC10783117
OpenAlexW4389315376

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.