ArticleAnalytical chemistry2023
Enzymatic Reactions Observed with Zero- and Low-Field Nuclear Magnetic Resonance.
Article in Analytical chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- First worldwide multicenter validation of the POLARIS preclinical polarizer across biological models and imaging paradigms.Research square · 2026Article
- Article
- Enabling nondestructive observation of electrolyte composition in batteries with ultralow-field nuclear magnetic resonance.Chemical science · 2026Article
- Article
- BiologicalSmall science · 2025Article
- Indirect Zero-Field Nuclear Magnetic Resonance Spectroscopy.Analytical chemistry · 2025Article
- The role of responsive MRI probes in the past and the future of molecular imaging.Chemical science · 2024Review
- Live magnetic observation of parahydrogen hyperpolarization dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We demonstrate that enzyme-catalyzed reactions can be observed in zero- and low-field NMR experiments by combining recent advances in parahydrogen-based hyperpolarization methods with state-of-the-art magnetometry. Specifically, we investigated two model biological processes: the conversion of fumarate into malate, which is used in vivo as a marker of cell necrosis, and the conversion of pyruvate into lactate, which is the most widely studied metabolic process in hyperpolarization-enhanced imaging. In addition to this, we constructed a microfluidic zero-field NMR setup to perform experiments on microliter-scale samples of [1-
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.