Evidence map›Paper›PMID 38047498›Full record

ArticleAnalytical chemistry2023

Top/Middle-Down Characterization of α-Synuclein Glycoforms.

Samuel A Miller, Kevin Jeanne Dit Fouque, Eldon R Hard, Aaron T Balana, Desmond Kaplan, Valery G Voinov, Mark E Ridgeway, Melvin A Park, Gordon A Anderson, Matthew R Pratt and 1 more

Open access · greenAbstract read
In one paragraph

Article in Analytical chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Analytical applications of gas-phase ion chemistry enabled by mass spectrometry.Analytical methods : advancing methods and applications · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Samuel A MillerDepartment of Chemistry and Biochemistry and Biomolecular Sciences Institute, Florida International University, Miami, Florida 33199, United States.
Kevin Jeanne Dit FouqueDepartment of Chemistry and Biochemistry and Biomolecular Sciences Institute, Florida International University, Miami, Florida 33199, United States.
Eldon R HardDepartment of Chemistry and Biological Sciences, University of Southern California, Los Angeles, California 90007, United States.
Aaron T BalanaDepartment of Chemistry and Biological Sciences, University of Southern California, Los Angeles, California 90007, United States.
Desmond KaplanKapScience LLC, Tewksbury, Massachusetts 01876, United States.ORCID 0000-0003-3597-1547
Valery G Voinove-MSion Inc., Corvallis, Oregon 97330, United States.
Mark E RidgewayBruker Daltonics Inc., Billerica, Massachusetts 01821, United States.
Melvin A ParkBruker Daltonics Inc., Billerica, Massachusetts 01821, United States.ORCID 0009-0004-1448-2896
Gordon A AndersonGAA Custom Electronics, Kennewick, Washington 99338, United States.
Matthew R PrattDepartment of Chemistry and Biological Sciences, University of Southern California, Los Angeles, California 90007, United States.ORCID 0000-0003-3205-5615
Francisco Fernandez-LimaDepartment of Chemistry and Biochemistry and Biomolecular Sciences Institute, Florida International University, Miami, Florida 33199, United States.ORCID 0000-0002-1283-4390
Florida International University · USUniversity of Southern California · USBruker (United States) · USCustom Electronics (United States) · USECD for the Masses (United States) · US

Funding

Functional Analysis of O-GlcNAc using Synthetic Protein ChemistryR01GM114537 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PRATT, MATTHEW ROBERT · 2015 to 2024
$3.1M
Development of Multidimensional, Linear and Differential Ion Mobility MS Separations for Middle-Down ProteoformsR01GM134247 · NIGMS · FLORIDA INTERNATIONAL UNIVERSITY · PI FERNANDEZ-LIMA, FRANCISCO · 2019 to 2022
$1.7M
NIGMS NIH HHS R01 GM114537NIGMS NIH HHS R01 GM134247
6 · The paper itself

Abstract

α-Synuclein is an intrinsically disordered protein that plays a critical role in the pathogenesis of neurodegenerative disorders, such as Parkinson's disease. Proteomics studies of human brain samples have associated the modification of the O-linked

Indexed as

alpha-SynucleinParkinson DiseaseHumansPeptide HydrolasesPeptidesProteolysisTandem Mass Spectrometryalpha-SynucleinPeptide HydrolasesPeptides

Identifiers

PMID38047498
PMCPMC10836061
OpenAlexW4389310715

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.