ArticleSkin health and disease2023
Primary penile melanoma and genital lichen sclerosus.
Article in Skin health and disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Sodium-glucose cotransporter-2 inhibitor therapy and penile lichen sclerosus: Clinical observations suggesting a role in disease development through urinary occlusion.International journal of STD & AIDS · 2026Article
- Case Report: Penile malignant melanoma: insights from a three-case series and literature review on diagnosis and management.Frontiers in oncology · 2026Article
- Lichen sclerosus in paediatric patients with phimosis undergoing circumcision.Skin health and disease · 2025Article
- Urine and occlusion in the pathogenesis of lichen sclerosus: insights from a case of post-urethrectomy remission.Skin health and disease · 2025Article
- Regional Variations in the Incidence of Lichen Sclerosus in Sweden: Insights from a Nationwide Register Study (2001-2021).Journal of clinical medicine · 2024Article
- The clinical and dermatoscopic features of penile pigmentation in men with genital lichen sclerosus.Skin health and disease · 2024Article
- Exploring the Multifactorial Landscape of Penile Cancer: A Comprehensive Analysis of Risk Factors.Diagnostics (Basel, Switzerland) · 2024Review
- The acronymisation of lichen sclerosus.Skin health and disease · 2024Article
- Primary vulval melanoma and genital lichen sclerosus.Skin health and disease · 2024Article
- Primary penile melanoma and genital lichen sclerosus.Skin health and disease · 2023Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: There is a well-established association between squamous cell cancer and genital lichen sclerosus (GLSc). Although there have been several reported cases of vulval melanoma (MM) associated with LSc, particularly in the paediatric population, fewer cases of male genital (M) GLSc and penile (Pe)MM have been published. Objectives: The aim of this study was to explore further the relationship between PeMM and MGLSc by reviewing all the cases managed by our multidisciplinary service over a finite period. Methods: All patients known to our tertiary urology and male genital dermatology service with a diagnosis of PeMM and where histology was available for review were identified over an 11-year period (2011-2022). The histology was reviewed by two independent, mutually 'blinded' histopathologists. Photographs and clinical notes, where available, were retrospectively reviewed by two independent dermatologists for signs or symptoms of LSc. Results: Eleven patients with PeMM were identified for review. Histopathological examination found evidence of LSc in nine patients, and review of clinical photos corroborated the presence of LSc in three. Overall, features of LSc were present in nine out of eleven cases (82%). Conclusion: The presence of LSc in 9 out of 11 cases of PeMM is suggestive of a causative relationship between LSc and PeMM. This may be due to chronic melanocytic distress created by chronic inflammation secondary to LSc.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.