Evidence map›Paper›PMID 38047080›Full record

ArticleiScience2023

Modeling early treatment response in AML from cell-free tumor DNA.

Dantong Wang, Christian Rausch, Simon A Buerger, Sebastian Tschuri, Maja Rothenberg-Thurley, Melanie Schulz, Jan Hasenauer, Frank Ziemann, Klaus H Metzeler, Carsten Marr

Abstract read
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dantong WangInstitute of AI for Health, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg 85764, Germany.
Christian RauschLaboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital (LMU), Munich, Germany.
Simon A BuergerLaboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital (LMU), Munich, Germany.
Sebastian TschuriLaboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital (LMU), Munich, Germany.
Maja Rothenberg-ThurleyLaboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital (LMU), Munich, Germany.
Melanie SchulzInstitute of AI for Health, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg 85764, Germany.
Jan HasenauerCenter for Mathematics, Technische Universität München, Garching 85748, Germany.
Frank ZiemannLaboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital (LMU), Munich, Germany.
Klaus H MetzelerDepartment of Hematology and Cell Therapy, University Hospital Leipzig (UHL) 04103, Germany.
Carsten MarrInstitute of AI for Health, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg 85764, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monitoring disease response after intensive chemotherapy for acute myeloid leukemia (AML) currently requires invasive bone marrow biopsies, imposing a significant burden on patients. In contrast, cell-free tumor DNA (ctDNA) in peripheral blood, carrying tumor-specific mutations, offers a less-invasive assessment of residual disease. However, the relationship between ctDNA levels and bone marrow blast kinetics remains unclear. We explored this in 10 AML patients with

Indexed as

Biological sciencesDisease

Identifiers

PMID38047080
PMCPMC10690559

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.