Evidence map›Paper›PMID 38047073›Full record

ArticleiScience2023

Hepatic

William W Feng, Scott Bang, Eric M Takacs, Cora Day, Katherine J Crawford, Ruba Al-Sheyab, Dara B Almufarrej, Wendy Wells, Serguei Ilchenko, Takhar Kasumov and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

William W FengDepartment of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
Scott BangDepartment of Biological Sciences, Kent State University, Kent, OH 44242, USA.
Eric M TakacsDepartment of Biological Sciences, Kent State University, Kent, OH 44242, USA.
Cora DayDepartment of Biological Sciences, Kent State University, Kent, OH 44242, USA.
Katherine J CrawfordDepartment of Biological Sciences, Kent State University, Kent, OH 44242, USA.
Ruba Al-SheyabSchool of Biomedical Sciences, Kent State University, Kent, OH 44240, USA.
Dara B AlmufarrejSchool of Biomedical Sciences, Kent State University, Kent, OH 44240, USA.
Wendy WellsDepartment of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA.
Serguei IlchenkoDepartment of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
Takhar KasumovDepartment of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
Ning KonDepartment of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.
Colleen M NovakDepartment of Biological Sciences, Kent State University, Kent, OH 44242, USA.
Wei GuDepartment of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.
Manabu KurokawaDepartment of Biological Sciences, Kent State University, Kent, OH 44242, USA.

Funding

Neural Mechanisms Underlying Central Induction of Skeletal Muscle ThermogenesisR15DK121246 · NIDDK · KENT STATE UNIVERSITY · PI NOVAK, COLLEEN M · 2020 to 2024
$906k
Molecular mechanisms of chemoresistance in breast cancerR00CA140948 · NCI · DARTMOUTH COLLEGE · PI KUROKAWA, MANABU · 2012 to 2014
$708k
Mechanisms Underlying Contextual Induction of Muscle ThermogenesisR15DK108668 · NIDDK · KENT STATE UNIVERSITY · PI NOVAK, COLLEEN M · 2016 to 2016
$450k
Role of CD36 and diet-derived fatty acids in breast cancerR15CA256838 · NCI · KENT STATE UNIVERSITY · PI KUROKAWA, MANABU · 2021 to 2021
$445k
Role of the ubiquitin E3 ligase HUWE1 in age-associated nonalcoholic fatty liver diseaseR21AG081896 · NIA · KENT STATE UNIVERSITY · PI KUROKAWA, MANABU · 2023 to 2024
$433k
Defining the in vivo role of Huwe1 in p53 regulationR03CA230828 · NCI · KENT STATE UNIVERSITY · PI KUROKAWA, MANABU · 2018 to 2019
$150k
NCI NIH HHS R00 CA140948NCI NIH HHS R03 CA230828NCI NIH HHS R15 CA256838NIA NIH HHS R21 AG081896NIDDK NIH HHS R15 DK108668NIDDK NIH HHS R15 DK121246
6 · The paper itself

Abstract

Non-alcoholic fatty liver disease (NAFLD) is the most pervasive liver pathology worldwide. Here, we demonstrate that the ubiquitin E3 ligase Huwe1 is vital in NAFLD pathogenesis. Using mass spectrometry and RNA sequencing, we reveal that liver-specific deletion of Huwe1 (

Indexed as

BiochemistryPathophysiology

Identifiers

PMID38047073
PMCPMC10692727

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.