ArticleCureus2023
Choroidal Morphology and Systemic Circulation Changes During the Menstrual Cycle in Healthy Japanese Women.
Article in Cureus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- OCTA-based assessment of macular and peripapillary vessel changes during the menstrual cycle.BMC ophthalmology · 2025Article
- Macular, choroidal and disc associations across women's reproductive life stages: a scoping review from menarche to post-menopause.Eye (London, England) · 2025Article
- Variabilities in Retinal Hemodynamics Across the Menstrual Cycle in Healthy Women Identified Using Optical Coherence Tomography Angiography.Life (Basel, Switzerland) · 2024Article
- Investigation of Choroidal Circulation Hemodynamics Using Laser Speckle Flowgraphy After Periocular Skin Warming.Cureus · 2024Article
- Choroidal Thickness Increases During Parasympathetic Dominance After Immersion of the Foot in Warm Water.Cureus · 2024Article
- Retinal morphology across the menstrual cycle: insights from the UK Biobank.npj women's health · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeChanges in systemic circulatory dynamics and choroidal thickness are poorly understood. This study aimed to investigate the time course of changes in choroidal morphology during normal menstrual cycles in healthy women using enhanced depth imaging optical coherence tomography (EDI-OCT). MATERIALS AND
methodsThis prospective study included 15 left eyes of 15 healthy Japanese women (mean age, 20.2 ± 0.8 years) with a normal menstrual cycle. Using EDI-OCT, the subfoveal choroidal thickness (SCT) was manually measured during the late follicular and mid-luteal phases. Intraocular pressure (IOP), systolic, diastolic, and mean blood pressure (SBP, DBP, and MBP), and heart rate (HR) were also evaluated during these phases.
resultsSBP, DBP, and MBP were significantly elevated in the mid-luteal phase. The average SCT was significantly decreased in the mid-luteal phase. In contrast, there were no significant changes in IOP or HR.
conclusionThese findings indicate that choroidal thickness decreases during the mid-luteal phase in healthy Japanese women with normal menstrual cycles depending on systemic circulatory dynamics. However, since the difference in the SCT values between the late follicular and the mid-luteal phase is not large (7 μm), the menstrual cycle may have little influence on the interpretation of choroidal thickness data in clinical practice.
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Registered trials
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