Evidence map›Paper›PMID 38046430›Full record

ArticleThe Canadian veterinary journal = La revue veterinaire canadienne2023

Retrospective evaluation of toceranib phosphate (Palladia) use in the treatment of feline pancreatic carcinoma.

Carlos Ortiz Rosario, Margaret L Musser, Lignan Yuan, Jonathan P Mochel, Jessica Talbott, Chad M Johannes, Erika P Berger

Open access · greenAbstract read
In one paragraph

Article in The Canadian veterinary journal = La revue veterinaire canadienne, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Carlos Ortiz RosarioDepartment of Veterinary Clinical Science (Ortiz Rosario, Musser, Johannes, Berger) and Department of Veterinary Biomedical Science (Yuan, Mochel), Iowa State University College of Veterinary Medicine, 1800 Christensen Drive, Ames, Iowa 50011, USA; SMART Pharmacology, Iowa State University, 1800 Christensen Drive, Ames, Iowa 50011, USA (Yuan, Mochel); Angell Animal Medical Center, 350 S. Huntington Avenue, Boston, Massachusetts 02130, USA (Talbott).
Margaret L MusserDepartment of Veterinary Clinical Science (Ortiz Rosario, Musser, Johannes, Berger) and Department of Veterinary Biomedical Science (Yuan, Mochel), Iowa State University College of Veterinary Medicine, 1800 Christensen Drive, Ames, Iowa 50011, USA; SMART Pharmacology, Iowa State University, 1800 Christensen Drive, Ames, Iowa 50011, USA (Yuan, Mochel); Angell Animal Medical Center, 350 S. Huntington Avenue, Boston, Massachusetts 02130, USA (Talbott).
Lignan YuanDepartment of Veterinary Clinical Science (Ortiz Rosario, Musser, Johannes, Berger) and Department of Veterinary Biomedical Science (Yuan, Mochel), Iowa State University College of Veterinary Medicine, 1800 Christensen Drive, Ames, Iowa 50011, USA; SMART Pharmacology, Iowa State University, 1800 Christensen Drive, Ames, Iowa 50011, USA (Yuan, Mochel); Angell Animal Medical Center, 350 S. Huntington Avenue, Boston, Massachusetts 02130, USA (Talbott).
Jonathan P MochelDepartment of Veterinary Clinical Science (Ortiz Rosario, Musser, Johannes, Berger) and Department of Veterinary Biomedical Science (Yuan, Mochel), Iowa State University College of Veterinary Medicine, 1800 Christensen Drive, Ames, Iowa 50011, USA; SMART Pharmacology, Iowa State University, 1800 Christensen Drive, Ames, Iowa 50011, USA (Yuan, Mochel); Angell Animal Medical Center, 350 S. Huntington Avenue, Boston, Massachusetts 02130, USA (Talbott).
Jessica TalbottDepartment of Veterinary Clinical Science (Ortiz Rosario, Musser, Johannes, Berger) and Department of Veterinary Biomedical Science (Yuan, Mochel), Iowa State University College of Veterinary Medicine, 1800 Christensen Drive, Ames, Iowa 50011, USA; SMART Pharmacology, Iowa State University, 1800 Christensen Drive, Ames, Iowa 50011, USA (Yuan, Mochel); Angell Animal Medical Center, 350 S. Huntington Avenue, Boston, Massachusetts 02130, USA (Talbott).
Chad M JohannesDepartment of Veterinary Clinical Science (Ortiz Rosario, Musser, Johannes, Berger) and Department of Veterinary Biomedical Science (Yuan, Mochel), Iowa State University College of Veterinary Medicine, 1800 Christensen Drive, Ames, Iowa 50011, USA; SMART Pharmacology, Iowa State University, 1800 Christensen Drive, Ames, Iowa 50011, USA (Yuan, Mochel); Angell Animal Medical Center, 350 S. Huntington Avenue, Boston, Massachusetts 02130, USA (Talbott).
Erika P BergerDepartment of Veterinary Clinical Science (Ortiz Rosario, Musser, Johannes, Berger) and Department of Veterinary Biomedical Science (Yuan, Mochel), Iowa State University College of Veterinary Medicine, 1800 Christensen Drive, Ames, Iowa 50011, USA; SMART Pharmacology, Iowa State University, 1800 Christensen Drive, Ames, Iowa 50011, USA (Yuan, Mochel); Angell Animal Medical Center, 350 S. Huntington Avenue, Boston, Massachusetts 02130, USA (Talbott).
Iowa State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To retrospectively assess the biological response in cats with pancreatic carcinoma treated with toceranib phosphate. Animals: Twenty-six client-owned cats. Procedure: Patient information from multiple institutions was solicited Results: Twenty cats were treated for gross disease and 6 for microscopic disease/incomplete margins. Clinical benefit (complete response, partial response, or stable disease ≥ 10 wk) was observed in 9/20 cats treated in the gross disease setting (45%; complete response: Conclusion: Toceranib phosphate was well-tolerated and provided modest clinical benefit to a subset of cats treated. Clinical relevance: Although feline exocrine pancreatic carcinoma continues to be a challenging disease to treat, toceranib phosphate appeared to provide potential clinical benefit.

Indexed as

Antineoplastic AgentsCat DiseasesAnimalsCatsHumansIndolesPancreatic NeoplasmsPyrrolesRetrospective StudiesAntineoplastic AgentsIndolesPyrrolestoceranib phosphate

Identifiers

PMID38046430
PMCPMC10637710
OpenAlexW4389315610

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.